The use of indigocarmine spray increases the colonoscopic detection rate of adenomas

Togashi, Kazutomo, Hewett, David, Radford-Smith, Graham, Francis, Leo, Leggett, Barbara A. and Appleyard, Mark N. (2009) The use of indigocarmine spray increases the colonoscopic detection rate of adenomas. Journal of Gastroenterology, 44 8: 826-833. doi:10.1007/s00535-009-0065-3

Author Togashi, Kazutomo
Hewett, David
Radford-Smith, Graham
Francis, Leo
Leggett, Barbara A.
Appleyard, Mark N.
Title The use of indigocarmine spray increases the colonoscopic detection rate of adenomas
Journal name Journal of Gastroenterology   Check publisher's open access policy
ISSN 0944-1174
Publication date 2009-05-16
Year available 2009
Sub-type Article (original research)
DOI 10.1007/s00535-009-0065-3
Volume 44
Issue 8
Start page 826
End page 833
Total pages 8
Editor Mamoru Watanabe
Place of publication Japan
Publisher Springer Japan KK
Collection year 2010
Language eng
Subject C1
Formatted abstract
Purpose It remains controversial whether chromocolonoscopy using indigocarmine increases the detection of colorectal polyps. We aimed to assess the impact of indigocarmine dye spray on the detection rate of adenomas and the feasibility of learning the technique in a Western practice.
Methods 400 patients were prospectively allocated into 2 groups; A (n = 200): indigocarmine chromocolonoscopy was performed by a Japanese colonoscopist with expertise in chromoscopy; B (n = 200): initial 100 patients (B-1), a Western colonoscopist with no previous experience of chromoscopy performed conventional colonoscopy, but with at least 10 min observation during colonoscopy withdrawal. In the next 100 patients (B-2), he performed chromocolonoscopy. All polyps found were resected. Regression analysis was used to compare the numbers of polyps detected in groups A, B-1 and B-2, whilst controlling for gender, age, indication and history of colorectal cancer.
Results There were significant differences in the numbers of neoplastic polyps and flat adenomas between groups A and B-1 as well as between B-1 and B-2, but not between A and B-2. There was no significant difference in numbers of advanced lesions. Chromocolonoscopy (A and B-2) detected more neoplastic polyps of ≤5 mm.
Conclusion Chromocolonoscopy increases the detection of neoplastic polyps and flat adenomas, particularly diminutive polyps, but does not increase the detection of advanced lesions.
Keyword Colonoscopy
Colon polyp
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 17 Mar 2010, 20:24:43 EST by Amanda Jones on behalf of Medicine - Royal Brisbane and Women's Hospital