Clean Or dirty - Just how selective do drugs need to be?

Abbenante, Giovanni, Reid, Robert C. and Fairlie, David P. (2008) Clean Or dirty - Just how selective do drugs need to be?. Australian Journal of Chemistry, 61 9: 654-660. doi:10.1071/CH08186


Author Abbenante, Giovanni
Reid, Robert C.
Fairlie, David P.
Title Clean Or dirty - Just how selective do drugs need to be?
Journal name Australian Journal of Chemistry   Check publisher's open access policy
ISSN 0004-9425
1448-0038
Publication date 2008
Sub-type Article (original research)
DOI 10.1071/CH08186
Open Access Status
Volume 61
Issue 9
Start page 654
End page 660
Total pages 17
Place of publication Melbourne, Vic. Australia
Publisher Commonwealth Scientific and Industrial Research Organization (CSIRO) in co-operation with the Australian Academy of Science
Language eng
Subject 0303 Macromolecular and Materials Chemistry
0399 Other Chemical Sciences
Abstract Chemotherapy has developed largely on the basis of searching for chemicals with selective toxicity, targeting a specific step or receptor in a disease process without negatively impacting on normal physiology. The desire for ‘clean’ drugs that act on a single target and thus avoid side effects has led to ever-increasing timeframes for introducing new drugs to humans. This has led to reappraisal of how selective drugs need to be. Examples here of compounds from common drug classes (kinase inhibitors, protease inhibitors, G protein coupled receptors ligands, non-steroidal anti-inflammatory drugs, statins, antibodies) highlight current debate on the merits of target selectivity versus target promiscuity in the development of drugs for inflammation, cancer, cardiovascular, central nervous system and infectious diseases.
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 17 Mar 2010, 13:58:11 EST by Ms Lynette Adams on behalf of Institute for Molecular Bioscience