Determinants of mean glomerular volume in the human kidney

Samuel, T., Douglas-Denton, R., Hughson, M. D., Bertram, J. F. and Hoy, W. E. (2004). Determinants of mean glomerular volume in the human kidney. In: Nephrology: 40th Annual Scientific Meeting of the Australian & New Zealand Society of Nephrology. 40th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Adelaide Convention Centre, Adelaide, Australia, (A11-A11). 1–3 September, 2004.

Author Samuel, T.
Douglas-Denton, R.
Hughson, M. D.
Bertram, J. F.
Hoy, W. E.
Title of paper Determinants of mean glomerular volume in the human kidney
Conference name 40th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology
Conference location Adelaide Convention Centre, Adelaide, Australia
Conference dates 1–3 September, 2004
Proceedings title Nephrology: 40th Annual Scientific Meeting of the Australian & New Zealand Society of Nephrology   Check publisher's open access policy
Place of Publication Carlton, Vic. Australia
Publisher Blackwell Science
Publication Year 2004
ISSN 1320-5358
1440-1797
Volume 9
Issue Supp. 1
Start page A11
End page A11
Total pages 1
Language eng
Abstract/Summary Background: We previously reported the range and correlations of mean glomerular volume (Vglom) in kidneys in 116 people at autopsy after unexpected death (Hoy et al. Nephrology 7:A55, 2002). We now update those findings and present newly defined associations, the study now includes nearly twice as many people. There are 208 participants: 92 US Blacks, 73 US Whites, 19 Aboriginal Australians and 24 nonAboriginal Australians, aged <1 day to 85 years, and 191 adults (18 + years). Methods: The right kidney was isolated and perfusion-fixed. Stereological estimates of glomerular number (Nglom) and Vglom were obtained using the disector/fractionator combination. Results: Vglom ranged from 0.85 to 16.99 mm3 ¥ 106. It correlated with age in children, a function of increasing BSA, with a predicted increase of 3.2 mm3 ¥ 106 per m2 increase in BSA (R2 = 0.905, p < 0.0001). Vglom in adults showed a 5.1-fold range, from 3.29 to 16.99 mm3 ¥ 106, mean (SD) 7.92 (2.09). Factors independently correlated with Vglom in adults were Nglom, BSA and Black race. Multivariate analysis predicted an increase in Vglom of 4.06 mm3 ¥ 106 per million fewer glomeruli (P < 0.0001) and an increase in Vglom of 2.4 mm3 ¥ 106 per m2 increase in BSA (P < 0.0001), both considerably stronger relationships than reported previously. Black race also predicted an increase in Vglom of 1.13 mm3 ¥ 106 (P < 0.03), a new finding. Increase in Vglom with age was explained totally by the reduction in Nglom with age. Conclusion: Vglom varies widely in adults and is markedly influenced by reduced nephron number, higher BSAs and black race. Compensatory enlargement of glomeruli is generally insufficient to normalize total glomerular mass. Excessive enlargement compromises glomerular survival (Brenner et al. AJKD 22 : 98–104, 1993). Reduced nephron number, excessive body size and racial origin probably all enhance susceptibility to renal insufficiency
Subjects 110312 Nephrology and Urology
1103 Clinical Sciences
Keyword Renal disease
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Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

 
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Created: Wed, 17 Mar 2010, 20:49:33 EST by Therese Egan on behalf of Faculty Of Health Sciences