A prospective study of albuminuria and incident coronary heart disease in Aboriginal people

Wang, Z. and Hoy, W. E. (2004). A prospective study of albuminuria and incident coronary heart disease in Aboriginal people. In: Nephrology: 40th Annual Scientific Meeting of the Australian & New Zealand Society of Nephrology. 40th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Adelaide Convention Centre, Adelaide, Australia, (A2-A2). 1–3 September, 2004.


Author Wang, Z.
Hoy, W. E.
Title of paper A prospective study of albuminuria and incident coronary heart disease in Aboriginal people
Conference name 40th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology
Conference location Adelaide Convention Centre, Adelaide, Australia
Conference dates 1–3 September, 2004
Proceedings title Nephrology: 40th Annual Scientific Meeting of the Australian & New Zealand Society of Nephrology   Check publisher's open access policy
Place of Publication Carlton, Vic. Australia
Publisher Blackwell Science
Publication Year 2004
Sub-type Poster
ISSN 1320-5358
1440-1797
Volume 9
Issue Supp. 1
Start page A2
End page A2
Total pages 1
Language eng
Abstract/Summary Australian Aborigines have exceedingly high rates of renal failure together with increased cardiovascular mortality. We examined the relation between microand marcro-albuminuria and incident coronary heart disease (CHD) in a population of 871 Aboriginal adults aged 20–74 years without prevalent baseline CHD, who were followed up to May 2003 from the baseline examination (1992–2005). At baseline, participants were categorised into normoalbuminuria, microalbuminuria, and macroalbuminuria groups. CHD events were identified from hospital and death records using the codes of the International Classification of Disease (ICD-9-CM codes 410–414 and ICD-10-AM code I20-I25). Only first CHD incidents (fatal or nonfatal) were included in this study. During a median of 8.7 years of follow-up, 87 new CHD events occurred during the followup period (1992–2003). The incidence of CHD increased significantly across categories of albuminuria (4.4, 13.2, and 32.6/1000 perso-years for normoalbuminuria, microalbuminuria and macroalbuminuria, respectively). The cumulative CHD incidences by albuminuria status are shown in Fig. 1. Rate ratios for CHD were 2.1 (95% confidence interval (CI: 1.1, 4.0) for microalbuminuria and 4.3 (95% CI: 2.4, 7.8) for macroalbuminuria, adjusting for age and sex using Cox proportional hazards method. With adjustment for age, sex, blood pressure, total cholesterol, diabetes status, cigarette smoke and alcohol consumption, rate ratios for CHD were 2.0 (95% CI: 1.0, 4.0) for microalbuminuria and 2.6 (95% CI: 1.3, 5.4) for macroalbuminuria. About 15% (95% CI 0, 29) CHD risk in the study population was attributable to microalbuminuria and 32% (95% CI: 7, 50) to macroalbuminuria. Independent of traditional cardiovascular risk factors, both microalbuminuria and macroalbuminuria are useful in identifying increased risk of CHD in Aboriginal people.
Subjects 110312 Nephrology and Urology
1103 Clinical Sciences
Keyword Heart disease
Indigenous Australians
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Wed, 17 Mar 2010, 10:11:21 EST by Therese Egan on behalf of Faculty Of Health Sciences