An adhesion molecule in free-living Dictyostelium amoebae with integrin beta features

Cornillon, Sophie, Gebbie, Leigh, Benghezal Mohammed, Nair, Prashant, Keller, Sebastien, Wehrle-Haller, Bernhard, Charette, Steve J., Brückert, Franz, Letourneur, François and Cosson, Pierre (2006) An adhesion molecule in free-living Dictyostelium amoebae with integrin beta features. EMBO reports, 7 6: 617-621. doi:10.1038/sj.embor.7400701


Author Cornillon, Sophie
Gebbie, Leigh
Benghezal Mohammed
Nair, Prashant
Keller, Sebastien
Wehrle-Haller, Bernhard
Charette, Steve J.
Brückert, Franz
Letourneur, François
Cosson, Pierre
Title An adhesion molecule in free-living Dictyostelium amoebae with integrin beta features
Formatted title
An adhesion molecule in free-living Dictyostelium amoebae with integrin β features
Journal name EMBO reports   Check publisher's open access policy
ISSN 1469-3178
1469-221X
Publication date 2006-06-01
Sub-type Article (original research)
DOI 10.1038/sj.embor.7400701
Volume 7
Issue 6
Start page 617
End page 621
Total pages 5
Editor Frank Gannon
Place of publication Oxford, U.K.
Publisher Nature Publishing Group
Language eng
Subject 0601 Biochemistry and Cell Biology
Formatted abstract
The study of free-living amoebae has proven valuable to explain the molecular mechanisms controlling phagocytosis, cell adhesion and motility. In this study, we identified a new adhesion molecule in Dictyostelium amoebae. The SibA (Similar to Integrin Beta) protein is a type I transmembrane protein, and its cytosolic, transmembrane and extracellular domains contain features also found in integrin β chains. In addition, the conserved cytosolic domain of SibA interacts with talin, a well-characterized partner of mammalian integrins. Finally, genetic inactivation of SIBA affects adhesion to phagocytic particles, as well as cell adhesion and spreading on its substrate. It does not visibly alter the organization of the actin cytoskeleton, cellular migration or multicellular development. Our results indicate that the SibA protein is a Dictyostelium cell adhesion molecule presenting structural and functional similarities to metazoan integrin β chains. This study sheds light on the molecular mechanisms controlling cell adhesion and their establishment during evolution.
©2006 European Molecular Biology Organisation.

Keyword Phagocytosis
Dictyostelium
SibA protein
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Tue, 16 Mar 2010, 15:45:53 EST by June Temby on behalf of Aust Institute for Bioengineering & Nanotechnology