Biventricular diastolic behaviour in patients with hypertrophic and hereditary hemochromatosis cardiomyopathies

Palka, Przemysław, Lange, Aleksandra, Atherton, John, Stafford, Wayne J. and Burstow, Darryl J. (2004) Biventricular diastolic behaviour in patients with hypertrophic and hereditary hemochromatosis cardiomyopathies. European Journal of Echocardiography, 5 5: 356-366. doi:10.1016/j.euje.2004.01.003


Author Palka, Przemysław
Lange, Aleksandra
Atherton, John
Stafford, Wayne J.
Burstow, Darryl J.
Title Biventricular diastolic behaviour in patients with hypertrophic and hereditary hemochromatosis cardiomyopathies
Journal name European Journal of Echocardiography   Check publisher's open access policy
ISSN 1525-2167
Publication date 2004-10-01
Sub-type Article (original research)
DOI 10.1016/j.euje.2004.01.003
Volume 5
Issue 5
Start page 356
End page 366
Total pages 11
Place of publication London, U.K.
Publisher Oxford University Press
Language eng
Subject 11 Medical and Health Sciences
1103 Clinical Sciences
Formatted abstract
 Aim: To define biventricular diastolic behaviour in patients with cardiomyopathies with predominant diastolic left ventricular (LV) dysfunction.

Methods and results: Doppler tissue echocardiography and both mitral and tricuspid Doppler inflow profiles were investigated in hypertrophic (n = 17), hereditary hemochromatosis (n = 12) cardiomyopathies and age-matched normals (n = 31). The cardiomyopathy group had both lower early diastolic mitral lateral annular (El), cm/s (13.9±6.5) and medial (Em) (10.0±4.5) velocities compared with normals (19.5±5.5, 15.9±3.4, p<0.01, respectively). In the cardiomyopathy group, late isovolumic relaxation myocardial velocity gradient (IVR-MVG) (s−1) was positive compared with negative in normals (1.3±1.3 vs. −0.7±1.4, p<0.01, respectively). In both the cardiomyopathy group and in normals the onset of the tricuspid E-wave preceded the onset of the mitral E-wave. However, the onset of early diastolic tricuspid annular (Et) motion preceded the onset of El (ms) only in normals, but not in the cardiomyopathies (43±26 vs. −8±44, p<0.01, respectively). In the cardiomyopathy group there was a positive correlation between the onset of Et and abnormally positive late IVR-MVG (r = 0.51, p = 0.002).
Conclusions: Biventricular early diastolic behaviour is abnormal in the selected group of cardiomyopathy patients. The delay in the Et (early diastolic longitudinal right ventricular relaxation) may have a negative effect on LV diastolic function.

Keyword Cardiomyopathies
Diastolic dysfunction
Doppler echocardiography
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 17 Mar 2010, 01:37:27 EST by Ms May Balasaize on behalf of Faculty Of Health Sciences