Synergistic control of cellular adhesion by transmembrane 9 proteins

Benghezal, Mohammed, Cornillon, Sophie, Gebbie, Leigh, Alibaud, Laeticia, Brückert, Franz, Letourneur, François and Cosson, Pierre (2003) Synergistic control of cellular adhesion by transmembrane 9 proteins. Molecular Biology of The Cell, 14 7: 2890-2899. doi:10.1091/mbc.E02-11-0724

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Author Benghezal, Mohammed
Cornillon, Sophie
Gebbie, Leigh
Alibaud, Laeticia
Brückert, Franz
Letourneur, François
Cosson, Pierre
Title Synergistic control of cellular adhesion by transmembrane 9 proteins
Journal name Molecular Biology of The Cell   Check publisher's open access policy
ISSN 1059-1524
Publication date 2003-07
Sub-type Article (original research)
DOI 10.1091/mbc.E02-11-0724
Open Access Status File (Publisher version)
Volume 14
Issue 7
Start page 2890
End page 2899
Total pages 10
Editor David Botstein
Place of publication Bethesda, MD, U.S.A.
Publisher American Society for Cell Biology
Language eng
Subject 0601 Biochemistry and Cell Biology
Formatted abstract
The transmembrane 9 (TM9) family of proteins contains numerous members in eukaryotes. Although their function remains essentially unknown in higher eukaryotes, the Dictyostelium discoideum Phg1a TM9 protein was recently reported to be essential for cellular adhesion and phagocytosis. Herein, the function of Phg1a and of a new divergent member of the TM9 family called Phg1b was further investigated in D. discoideum. The phenotypes of PHG1a, PHG1b, and PHG1a/PHG1b double knockout cells revealed that Phg1a and Phg1b proteins play a synergistic but not redundant role in cellular adhesion, phagocytosis, growth, and development. Complementation analysis supports a synergistic regulatory function rather than a receptor role for Phg1a and Phg1b proteins. Together, these results suggest that Phg1 proteins act as regulators of cellular adhesion, possibly by controlling the intracellular transport in the endocytic pathway and the composition of the cell surface.
© 2003 by The American Society for Cell Biology.
Keyword Dictyostelium discoideum
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Article published online ahead of print. Mol. Biol. Cell 10.1091/mbc.E02–11–0724. Article and publication date are available at–11–0724.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 16 Mar 2010, 15:19:52 EST by June Temby on behalf of Aust Institute for Bioengineering & Nanotechnology