Phg2, a kinase involved in adhesion and focal site modeling in Dictyostelium

Gebbie, Leigh, Benghezal, Mohammed, Cornillon, Sophie, Froquet, Romain, Cherix, Nathalie, Malbouyres, Marilyne, Lefkir, Yaya, Grangeasse, Christophe, Fache, Sébastien, Dalous, Jérémie, Brückert, Franz, Letourneur, François and Cosson, Pierre (2004) Phg2, a kinase involved in adhesion and focal site modeling in Dictyostelium. Molecular Biology of The Cell, 15 8: 3915-3925. doi:10.1091/mbc.E03-12-0908

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Author Gebbie, Leigh
Benghezal, Mohammed
Cornillon, Sophie
Froquet, Romain
Cherix, Nathalie
Malbouyres, Marilyne
Lefkir, Yaya
Grangeasse, Christophe
Fache, Sébastien
Dalous, Jérémie
Brückert, Franz
Letourneur, François
Cosson, Pierre
Title Phg2, a kinase involved in adhesion and focal site modeling in Dictyostelium
Formatted title
Phg2, a kinase involved in adhesion and focal site modeling in Dictyostelium
Journal name Molecular Biology of The Cell   Check publisher's open access policy
ISSN 1059-1524
1939-4586
Publication date 2004-08
Sub-type Article (original research)
DOI 10.1091/mbc.E03-12-0908
Open Access Status File (Publisher version)
Volume 15
Issue 8
Start page 3915
End page 3925
Total pages 11
Editor David Botstein
Place of publication Bethesda, MD, U.S.A.
Publisher American Society for Cell Biology
Language eng
Formatted abstract
The amoeba Dictyostelium is a simple genetic system for analyzing substrate adhesion, motility and phagocytosis. A new adhesion-defective mutant named phg2 was isolated in this system, and PHG2 encodes a novel serine/threonine kinase with a ras-binding domain. We compared the phenotype of phg2 null cells to other previously isolated adhesion mutants to evaluate the specific role of each gene product. Phg1, Phg2, myosin VII, and talin all play similar roles in cellular adhesion. Like myosin VII and talin, Phg2 also is involved in the organization of the actin cytoskeleton. In addition, phg2 mutant cells have defects in the organization of the actin cytoskeleton at the cell-substrate interface, and in cell motility. Because these last two defects are not seen in phg1, myoVII, or talin mutants, this suggests a specific role for Phg2 in the control of local actin polymerization/depolymerization. This study establishes a functional hierarchy in the roles of Phg1, Phg2, myosinVII, and talin in cellular adhesion, actin cytoskeleton organization, and motility.
© 2004 by The American Society for Cell Biology.

Keyword Dictyostelium
Phagocytosis
phg2
myosin VII
talin
Polymerization/depolymerization
Q-Index Code C1
Additional Notes Article published online ahead of print. Mol. Biol. Cell 10.1091/mbc.E03–12–0908. Article and publication date are available at www.molbiolcell.org/cgi/doi/10.1091/mbc.E03–12–0908.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Tue, 16 Mar 2010, 15:02:22 EST by June Temby on behalf of Aust Institute for Bioengineering & Nanotechnology