Strong Amerind/White sex bias and a possible sephardic contribution among the founders of a population in Northwest Colombia

Carvajal-Carmona, Luis G., Soto, Iván D., Pineda, Nicolás, Ortíz-Barrientos, Daniel, Duque, Constanza, Ospina-Duque, Jorge, McCarthy, Mark, Montoya, Patricia, Alvarez, Victor M., Bedoya, Gabriel and Ruiz-Linares, Andrés (2000) Strong Amerind/White sex bias and a possible sephardic contribution among the founders of a population in Northwest Colombia. The American Journal of Human Genetics, 67 5: 1287-1295. doi:10.1016/S0002-9297(07)62956-5


Author Carvajal-Carmona, Luis G.
Soto, Iván D.
Pineda, Nicolás
Ortíz-Barrientos, Daniel
Duque, Constanza
Ospina-Duque, Jorge
McCarthy, Mark
Montoya, Patricia
Alvarez, Victor M.
Bedoya, Gabriel
Ruiz-Linares, Andrés
Title Strong Amerind/White sex bias and a possible sephardic contribution among the founders of a population in Northwest Colombia
Journal name The American Journal of Human Genetics   Check publisher's open access policy
ISSN 0002-9297
1537-6605
Publication date 2000-11-01
Sub-type Article (original research)
DOI 10.1016/S0002-9297(07)62956-5
Volume 67
Issue 5
Start page 1287
End page 1295
Total pages 9
Place of publication Oxford, UK
Publisher Elseiver
Language eng
Subject 0603 Evolutionary Biology
0604 Genetics
Abstract Historical and genetic evidences suggest that the recently founded population of Antioquia (Colombia) is potentially useful for the genetic mapping of complex traits. This population was established in the 16th–17th centuries through the admixture of Amerinds, Europeans, and Africans and grew in relative isolation until the late 19th century. To examine the origin of the founders of Antioquia, we typed 11 markers on the nonrecombining portion of the Y chromosome and four markers on mtDNA in a sample of individuals with confirmed Antioquian ancestry. The polymorphisms on the Y chromosome (five biallelic markers and six microsatellites) allow an approximation to the origin of founder men, and those on mtDNA identify the four major founder Native American lineages. These data indicate that ∼94% of the Y chromosomes are European, 5% are African, and 1% are Amerind. Y-chromosome data are consistent with an origin of founders predominantly in southern Spain but also suggest that a fraction came from northern Iberia and that some possibly had a Sephardic origin. In stark contrast with the Y-chromosome, ∼90% of the mtDNA gene pool of Antioquia is Amerind, with the frequency of the four Amerind founder lineages being closest to Native Americans currently living in the area. These results indicate a highly asymmetric pattern of mating in early Antioquia, involving mostly immigrant men and local native women. The discordance of our data with blood-group estimates of admixture suggests that the number of founder men was larger than that of women.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Biological Sciences Publications
Ecology Centre Publications
 
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Created: Mon, 15 Mar 2010, 09:43:23 EST by Laura McTaggart on behalf of Faculty of Science