Favorable mortality profile of naltrexone implants for opiate addiction

Reece, Albert Stuart (2010) Favorable mortality profile of naltrexone implants for opiate addiction. Journal of Addictive Diseases, 29 1: 30-50. doi:10.1080/10550880903435988


Author Reece, Albert Stuart
Title Favorable mortality profile of naltrexone implants for opiate addiction
Journal name Journal of Addictive Diseases   Check publisher's open access policy
ISSN 1055-0887
1545-0848
Publication date 2010-01
Sub-type Article (original research)
DOI 10.1080/10550880903435988
Volume 29
Issue 1
Start page 30
End page 50
Total pages 21
Place of publication Philadelphia, PA, United States
Publisher Routledge
Collection year 2011
Language eng
Abstract Several reports express concern at the mortality associated with the use of oral naltrexone for opiate dependency. Registry controlled follow-up of patients treated with naltrexone implant and buprenorphine was performed. In the study, 255 naltrexone implant patients were followed for a mean ( standard deviation) of 5.22 ± 1.87 years and 2,518 buprenorphine patients were followed for a mean ( standard deviation) of 3.19 ± 1.61 years, accruing 1,332.22 and 8,030.02 patient-years of follow-up, respectively. The crude mortality rates were 3.00 and 5.35 per 1,000 patient-years, respectively, and the age standardized mortality rate ratio for naltrexone compared to buprenorphine was 0.676 (95% confidence interval = 0.014 to 1.338). Most sex, treatment group, and age comparisons significantly favored the naltrexone implant group. Mortality rates were shown to be comparable to, and intermediate between, published mortality rates of an age-standardized methadone treated cohort and the Australian population. These data suggest that the mortality rate from naltrexone implant is comparable to that of buprenorphine, methadone, and the Australian population. Copyright © Taylor & Francis Group, LLC.
Keyword Heroin
Opiate
Naltrexone implant
Naltrexone depot
Registry controlled
Buprenorphine
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Sun, 14 Mar 2010, 00:04:25 EST