Ranked importance of outcomes of first-line versus repeated chemotherapy among ovarian cancer patients

Beesley, Vanessa L., Clavarino, Alexandra M., Webb, Penelope M., Wyld, David K., Francesconi, Alessandra B., Horwood, Keith R., Doecke, James D., Loos, Colleen A. and Green, Adele C. (2010) Ranked importance of outcomes of first-line versus repeated chemotherapy among ovarian cancer patients. Supportive Care in Cancer, 18 8: 943-949. doi:10.1007/s00520-009-0734-z

Author Beesley, Vanessa L.
Clavarino, Alexandra M.
Webb, Penelope M.
Wyld, David K.
Francesconi, Alessandra B.
Horwood, Keith R.
Doecke, James D.
Loos, Colleen A.
Green, Adele C.
Title Ranked importance of outcomes of first-line versus repeated chemotherapy among ovarian cancer patients
Journal name Supportive Care in Cancer   Check publisher's open access policy
ISSN 0941-4355
Publication date 2010-08
Sub-type Article (original research)
DOI 10.1007/s00520-009-0734-z
Volume 18
Issue 8
Start page 943
End page 949
Total pages 7
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2010
Language eng
Subject 111205 Chemotherapy
920507 Women's Health
920204 Evaluation of Health Outcomes
Formatted abstract
To examine the importance of possible outcomes of first-line versus repeated chemotherapy to ovarian cancer patients and to compare doctors' treatment intentions with patients' beliefs about cure.

Women with newly diagnosed (74) or relapsed (48) ovarian cancer were prospectively followed over 2 years. The level of importance they ascribed to four chemotherapy outcomes and their beliefs about cure were assessed. Their doctors independently specified intent of successive treatments.

Approximately half (54%) of newly diagnosed ovarian cancer patients (65% with residual disease >2 cm and 49% with no or ≤2 cm residual disease) ranked ‘tumour shrinkage (or decrease in blood levels of CA125)’ as ‘most important’ during first-line chemotherapy. Approximately two thirds (65–70%) of all women whose disease had relapsed also ranked ‘tumour shrinkage’ as ‘most important’ during repeated chemotherapy. Few women (<8%) rated symptom relief or absence of side-effects as most important. While both patients' and doctors' belief about cure decreased over successive treatments, patients grew more optimistic relative to doctors over time. Women's reports of advice by doctors about cure were consistent with doctors' stated intents for repeat chemotherapy. However, discordance between doctors' actual treatment intent and patients' beliefs about cure increased from 24% at first-line to 83% by fourth-line chemotherapy.


Women prioritise tumour response as the most important outcome of chemotherapy for ovarian cancer. This priority predominates in women with residual and relapsed disease despite declining likelihood of cure. Women may still hope for a cure while acknowledging their doctor's advice that their disease is incurable. Electronic supplementary material The online version of this article (doi:10.1007/s00520-009-0734-z) contains supplementary material, which is available to authorized users.
Keyword Ovarian cancer
Treatment goals and understanding
Belief in cure
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 12 Mar 2010, 16:42:08 EST by Charna Kovacevic on behalf of School of Pharmacy