Hyperaldosteronism causes volume overload cardiac hypertrophy in patients with resistant hypertension

Gaddam, Krishna K., Corros, Cecelia, Pimenta, Eduardo, Aban, Inmaculada, Inusah, Seidu, Gupta, Himanshu, Lloyd, Steven G., Oparil, Suzanne, Dell’Italia, Louis J., Husain, Ahsan and Calhoun, David (2008). Hyperaldosteronism causes volume overload cardiac hypertrophy in patients with resistant hypertension. In: Hypertension. Proceedings of: 62nd Annual High Blood Pressure Conference 2008. 62nd Annual High Blood Pressure Conference 2008, Atlanta, GA, U.S.A., (e76-e76). 17-20 September 2008. doi:10.1161/01.HYP.0000335249.42461.D0


Author Gaddam, Krishna K.
Corros, Cecelia
Pimenta, Eduardo
Aban, Inmaculada
Inusah, Seidu
Gupta, Himanshu
Lloyd, Steven G.
Oparil, Suzanne
Dell’Italia, Louis J.
Husain, Ahsan
Calhoun, David
Title of paper Hyperaldosteronism causes volume overload cardiac hypertrophy in patients with resistant hypertension
Conference name 62nd Annual High Blood Pressure Conference 2008
Conference location Atlanta, GA, U.S.A.
Conference dates 17-20 September 2008
Proceedings title Hypertension. Proceedings of: 62nd Annual High Blood Pressure Conference 2008   Check publisher's open access policy
Place of Publication Baltimore, MD, U.S.A.
Publisher Lippincott Williams & Wilkins
Publication Year 2008
Sub-type Poster
DOI 10.1161/01.HYP.0000335249.42461.D0
ISSN 0194-911X
1524-4563
Volume 52
Issue 4
Start page e76
End page e76
Total pages 1
Language eng
Formatted Abstract/Summary
Introduction
Aldosterone-induced left ventricular (LV) hypertrophy is attributed to direct effects of aldosterone separate from its classical hemodynamic effects. We hypothesized that aldosterone excess results in volume overload of the heart.

Conclusions
This study demonstrates that hyperaldosteronism causes a volume overload despite conventional diuretic therapy and RAS blockade without evidence of fibrosis in patients with resistant hypertension. Concomitant reductions in LV volume and mass without change in blood pressure or collagen products suggest volume overload as an important mechanism of aldosterone-induced LV hypertrophy. Thus, in patients with resistant hypertension and hyperaldosteronism, aldosterone-induced cardiac volume overload is a major determinant of LV hypertrophy and should be treated with aldosterone antagonists to reduce cardiovascular risk.
Subjects 1103 Clinical Sciences
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Presented as poster no.P104

 
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Created: Fri, 12 Mar 2010, 13:05:43 EST by Jon Swabey on behalf of Faculty Of Health Sciences