Acquired immunity to malaria

Doolan, Denise L., Dobano, Carlota and Baird, J. Kevin (2009) Acquired immunity to malaria. Clinical Microbiology Reviews, 22 1: 13-26. doi:10.1128/CMR.00025-08


Author Doolan, Denise L.
Dobano, Carlota
Baird, J. Kevin
Title Acquired immunity to malaria
Journal name Clinical Microbiology Reviews   Check publisher's open access policy
ISSN 0893-8512
1098-6618
Publication date 2009-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1128/CMR.00025-08
Volume 22
Issue 1
Start page 13
End page 26
Total pages 14
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Language eng
Subject 119999 Medical and Health Sciences not elsewhere classified
Abstract Naturally acquired immunity to falciparum malaria protects millions of people routinely exposed to Plasmodium falciparum infection from severe disease and death. There is no clear concept about how this protection works. There is no general agreement about the rate of onset of acquired immunity or what constitutes the key determinants of protection; much less is there a consensus regarding the mechanism(s) of protection. This review summarizes what is understood about naturally acquired and experimentally induced immunity against malaria with the help of evolving insights provided by biotechnology and places these insights in the context of historical, clinical, and epidemiological observations. We advocate that naturally acquired immunity should be appreciated as being virtually 100% effective against severe disease and death among heavily exposed adults. Even the immunity that occurs in exposed infants may exceed 90% effectiveness. The induction of an adult-like immune status among high-risk infants in sub-Saharan Africa would greatly diminish disease and death caused by P. falciparum. The mechanism of naturally acquired immunity that occurs among adults living in areas of hyper- to holoendemicity should be understood with a view toward duplicating such protection in infants and young children in areas of endemicity.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: ERA 2012 Admin Only
School of Medicine Publications
 
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