Spironolactone improves aldosterone related obstructive sleep apnea in subjects with resistant hypertension

Gaddam, Krishna K., Pimenta, Eduardo, Husain, Saima, Oparil, Suzanne and Calhoun, David A. (2008). Spironolactone improves aldosterone related obstructive sleep apnea in subjects with resistant hypertension. In: Abstracts of the American Society of Hypertension 23rd Annual Scientific Meeting. American Society of Hypertension (ASH) 23nd Annual Scientific Meeting and Exposition, New Orleans, LA., U.S.A., (A1-A2). 14-17 May 2008.

Author Gaddam, Krishna K.
Pimenta, Eduardo
Husain, Saima
Oparil, Suzanne
Calhoun, David A.
Title of paper Spironolactone improves aldosterone related obstructive sleep apnea in subjects with resistant hypertension
Conference name American Society of Hypertension (ASH) 23nd Annual Scientific Meeting and Exposition
Conference location New Orleans, LA., U.S.A.
Conference dates 14-17 May 2008
Proceedings title Abstracts of the American Society of Hypertension 23rd Annual Scientific Meeting   Check publisher's open access policy
Journal name Journal of Clinical Hypertension   Check publisher's open access policy
Place of Publication Hoboken, NJ, United States
Publisher Le Jacq Communications
Publication Year 2008
Sub-type Poster
Open Access Status
ISSN 1524-6175
1751-7176
Volume 10
Issue 5 Supp. A
Start page A1
End page A2
Total pages 2
Language eng
Formatted Abstract/Summary
Introduction
We have recently reported that obstructive sleep apnea (OSA) and primary aldosteronism are extremely common in subjects with resistant hypertension (RHTN) and that in these subjects, a significant correlation between serum aldosterone and OSA severity is observed. We hypothesized that aldosterone by increasing sodium and fluid retention worsens neck tissue edema and hence worsens sleep apnea.

Conclusion
These preliminary data support our hypothesis that aldosterone-related sodium and fluid retention may result in worsening of sleep apnea in subjects with resistant hypertension that can be partially overcome using mineralocorticoid antagonist spironolactone. Our findings potentially provide mechanistic insight into the relation between aldosterone related OSA and may be clinically important in treating these patients for better management of their hypertension and sleep apnea.
Subjects 1101 Medical Biochemistry and Metabolomics
1102 Cardiovascular Medicine and Haematology
1103 Clinical Sciences
Keyword Resistant hypertension
Obstructive sleep apnea
Primary aldosteronism
Spironolactone
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

 
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Created: Fri, 12 Mar 2010, 08:29:26 EST by Jon Swabey on behalf of Faculty Of Health Sciences