Booster vaccination of toddlers with reduced antigen content diphtheria-tetanus-acellular pertussis vaccine.

Nolan, Terry, Ruff, Tilman A., Lambert, Stephen B., Buttery, Jim, O'Grady, Kerry-Ann, Streeton, Catherine, Hoet, Bernard and Bock, Hans L. (2009) Booster vaccination of toddlers with reduced antigen content diphtheria-tetanus-acellular pertussis vaccine.. Vaccine, 27 18: 2410-2413. doi:10.1016/j.vaccine.2009.02.065


Author Nolan, Terry
Ruff, Tilman A.
Lambert, Stephen B.
Buttery, Jim
O'Grady, Kerry-Ann
Streeton, Catherine
Hoet, Bernard
Bock, Hans L.
Title Booster vaccination of toddlers with reduced antigen content diphtheria-tetanus-acellular pertussis vaccine.
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-410X
Publication date 2009-04
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.vaccine.2009.02.065
Volume 27
Issue 18
Start page 2410
End page 2413
Total pages 4
Place of publication United Kingdom
Publisher Elsevier Ltd
Collection year 2010
Language eng
Subject 060502 Infectious Agents
060506 Virology
920109 Infectious Diseases
C1
920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
920115 Respiratory System and Diseases (incl. Asthma)
Abstract Immunogenicity and reactogenicity of DTPa and reduced antigen dTpa booster vaccines were compared to a hepatitis A control vaccine in DTPa-primed toddlers aged 18-20 months. Post-booster, all DTPa and dTpa recipients were seroprotected against diphtheria and tetanus, >93.3% had a booster response to pertussis. There were similar reactogenicity rates in the DTPa and dTpa vaccine recipients. Few Grade 3 symptoms were reported. Just over one in four children in the control group had diphtheria antibody at or potentially below the correlate of protection benchmark (0.016 IU/ml). Larger studies should evaluate potential benefits of reduced antigen vaccines and seroprotection in children who do not receive a booster dose of DTPa at this age, including protection against diphtheria until subsequent booster doses are given. © 2009 Elsevier Ltd. All rights reserved.
Formatted abstract
I
Keyword vaccination
DTPa-HBV-IPV vaccine
Toddlers
booster
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Wed, 10 Mar 2010, 15:50:04 EST by Lesley Arnicar on behalf of Clinical Medical Virology Centre