Plasma ATP concentration and venous oxygen content in the forearm during dynamic handgrip exercise

Wood, R. E., Wishart, Connie, Walker, Philip J., Askew, Christopher D. and Stewart, Ian B. (2009) Plasma ATP concentration and venous oxygen content in the forearm during dynamic handgrip exercise. BMC Physiology, 9 24: x-x. doi:10.1186/1472-6793-9-24


Author Wood, R. E.
Wishart, Connie
Walker, Philip J.
Askew, Christopher D.
Stewart, Ian B.
Title Plasma ATP concentration and venous oxygen content in the forearm during dynamic handgrip exercise
Journal name BMC Physiology   Check publisher's open access policy
ISSN 1472-6793
Publication date 2009-12-15
Year available 2009
Sub-type Article (original research)
DOI 10.1186/1472-6793-9-24
Open Access Status DOI
Volume 9
Issue 24
Start page x
End page x
Total pages 9
Editor Melissa Norton
Place of publication London, UK
Publisher BioMed Central
Collection year 2010
Language eng
Subject 920103 Cardiovascular System and Diseases
1102 Cardiovascular Medicine and Haematology
C1
Abstract Background It has been proposed that adenosine triphosphate (ATP) released from red blood cells (RBCs) may contribute to the tight coupling between blood flow and oxygen demand in contracting skeletal muscle. To determine whether ATP may contribute to the vasodilatory response to exercise in the forearm, we measured arterialised and venous plasma ATP concentration and venous oxygen content in 10 healthy young males at rest, and at 30 and 180 seconds during dynamic handgrip exercise at 45% of maximum voluntary contraction (MVC). Results Venous plasma ATP concentration was elevated above rest after 30 seconds of exercise (P < 0.05), and remained at this higher level 180 seconds into exercise (P < 0.05 versus rest). The increase in ATP was mirrored by a decrease in venous oxygen content. While there was no significant relationship between ATP concentration and venous oxygen content at 30 seconds of exercise, they were moderately and inversely correlated at 180 seconds of exercise (r = -0.651, P = 0.021). Arterial ATP concentration remained unchanged throughout exercise, resulting in an increase in the venous-arterial ATP difference. Conclusions Collectively these results indicate that ATP in the plasma originated from the muscle microcirculation, and are consistent with the notion that deoxygenation of the blood perfusing the muscle acts as a stimulus for ATP release. That ATP concentration was elevated just 30 seconds after the onset of exercise also suggests that ATP may be a contributing factor to the blood flow response in the transition from rest to steady state exercise.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Mon, 08 Mar 2010, 14:40:17 EST by Kasia Moore on behalf of Surgery - Royal Brisbane and Women's Hospital