Antimalarial asexual stage-specific and gametocytocidal activities of HIV protease inhibitors

Peatey, Christopher L., Andrews, Katherine T., Eickel, Nina, MacDonald, Timothy, Butterworth, Alice S., Trenholme, Katharine R., Gardiner, Donald L., McCarthy, James S. and Skinner-Adams, Tina S. (2010) Antimalarial asexual stage-specific and gametocytocidal activities of HIV protease inhibitors. Antimicrobial Agents and Chemotherapy, 54 3: 1334-1337. doi:10.1128/AAC.01512-09

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ198049_OA.pdf Full text (open access) application/pdf 383.36KB 0

Author Peatey, Christopher L.
Andrews, Katherine T.
Eickel, Nina
MacDonald, Timothy
Butterworth, Alice S.
Trenholme, Katharine R.
Gardiner, Donald L.
McCarthy, James S.
Skinner-Adams, Tina S.
Title Antimalarial asexual stage-specific and gametocytocidal activities of HIV protease inhibitors
Journal name Antimicrobial Agents and Chemotherapy   Check publisher's open access policy
ISSN 0066-4804
Publication date 2010-03
Sub-type Article (original research)
DOI 10.1128/AAC.01512-09
Open Access Status File (Publisher version)
Volume 54
Issue 3
Start page 1334
End page 1337
Total pages 4
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2011
Language eng
Subject 1108 Medical Microbiology
0605 Microbiology
Formatted abstract
The stage-specific antimalarial activities of a panel of antiretroviral protease inhibitors (PIs), including two nonpeptidic PIs (tipranavir and darunavir), were tested in vitro against Plasmodium falciparum. While darunavir demonstrated limited antimalarial activity (effective concentration [EC50], >50 µM), tipranavir was active at clinically relevant concentrations (EC50, 12 to 21 µM). Saquinavir, lopinavir, and tipranavir preferentially inhibited the growth of mature asexual-stage parasites (24 h postinvasion). While all of the PIs tested inhibited gametocytogenesis, tipranavir was the only one to exhibit gametocytocidal activity.
Copyright © 2010, American Society for Microbiology. All Rights Reserved.

Keyword Antimalarial activities
Plasmodium falciparum
HIV protease inhibitors
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 07 Mar 2010, 00:08:38 EST