A smart glycol-directed nanodevice from rationally designed macroporous materials

Qian, K., Wan, J. J., Huang, X. D., Yang, P. Y., Liu, B. H. and Yu, C. Z. (2010) A smart glycol-directed nanodevice from rationally designed macroporous materials. Chemistry : A European Journal, 16 3: 822-828.


Author Qian, K.
Wan, J. J.
Huang, X. D.
Yang, P. Y.
Liu, B. H.
Yu, C. Z.
Title A smart glycol-directed nanodevice from rationally designed macroporous materials
Journal name Chemistry : A European Journal   Check publisher's open access policy
ISSN 0947-6539
1521-3765
Publication date 2010-01-18
Year available 2009
Sub-type Article (original research)
DOI 10.1002/chem.200902535
Volume 16
Issue 3
Start page 822
End page 828
Total pages 7
Place of publication Weinheim, Germany
Publisher Wiley
Collection year 2011
Language eng
Formatted abstract We have developed a smart nanodevice for the highly efficient and selective detection of glycoproteins. This polyfunctional device is fabricated through the rational functionalization of macroporous silica foam (MOSF) materials with a boron species (B- MOSF) and amino groups (NH2- MOSF), and then the integration of MOSF, B-MOSF and NH2-MOSF materials. In such a device, a macroporous structure with very large-pore sizes (di- ameters≈100 nm) and high-pore volumes (> 0.65 cm3 g-1) is advantageous to efficiently fasten the enzymatic reaction. The targeted specific glycopepti- des of the products can be selectively isolated and enriched in B-MOSF through the chemo-affinity between boronic acid and glycol groups, while the non-specific peptides are released to the solutions, or further purified by MOSF and NH 2-MOSF, which have opposite charges. As a result, the protein digestion and glycol-peptide isolation can be simultaneously achieved in the functionalized macroporous materials in one step, which is a great advantage compared to conventional multi-procedure and time-consuming techniques.
© 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
Keyword Glycolpepticles
Glycosylation
Macroporous materials
Nanotechnology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 18 DEC 2009

 
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