Whole parasite blood stage malaria vaccines: A convergence of evidence

McCarthy, James S. and Good, Michael F. (2010) Whole parasite blood stage malaria vaccines: A convergence of evidence. Human Vaccines, 6 1: 114-123. doi:10.4161/hv.6.1.10394

Author McCarthy, James S.
Good, Michael F.
Title Whole parasite blood stage malaria vaccines: A convergence of evidence
Journal name Human Vaccines   Check publisher's open access policy
ISSN 1554-8600
Publication date 2010-01
Sub-type Article (original research)
DOI 10.4161/hv.6.1.10394
Volume 6
Issue 1
Start page 114
End page 123
Total pages 10
Place of publication Austin, TX, United States
Publisher Landes Bioscience
Collection year 2011
Language eng
Abstract There is a growing realization of the limitations of recombinant protein-based malaria vaccines. This, coupled with a better understanding of the protective immunity to malaria, both in animal models and in naturally exposed human populations and experimentally infected volunteers, as well as the increased capacity to manipulate parasites provides new impetus to evaluate whole blood stage parasite approaches to malaria vaccine development. In this review previous studies in rodents and primates of whole killed and attenuated blood stage vaccines, and recent work on the effect of genetically attenuated parasites on immunity in rodent models of blood stage immunity are discussed. The relationship between these findings and what is now known about protective immunity in human populations, specifically against the blood stages of the parasite lifecycle is discussed and recent findings from human experimental infection are be reviewed. Finally, the prospect for and impediments to the development whole blood stage parasites are reviewed. © 2010 Landes Bioscience.
Keyword Malaria
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Created: Sun, 07 Mar 2010, 00:04:32 EST