Response to "Effective" plasma renin activity: A derived measure for assessing residual plasma renin activity in patients taking angiotensin-converting enzyme inhibitors or angiotensin receptor blockers

Pimenta, Eduardo and Calhoun, David A. (2010) Response to "Effective" plasma renin activity: A derived measure for assessing residual plasma renin activity in patients taking angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. Hypertension, 55 3: E17-E17. doi:10.1161/HYPERTENSIONAHA.109.148296


Author Pimenta, Eduardo
Calhoun, David A.
Title Response to "Effective" plasma renin activity: A derived measure for assessing residual plasma renin activity in patients taking angiotensin-converting enzyme inhibitors or angiotensin receptor blockers
Journal name Hypertension   Check publisher's open access policy
ISSN 0194-911X
1524-4563
0073-425X
Publication date 2010-03
Sub-type Discussion - responses, round table/panel discussions, Q&A, reply
DOI 10.1161/HYPERTENSIONAHA.109.148296
Open Access Status
Volume 55
Issue 3
Start page E17
End page E17
Total pages 1
Editor John E. Hall
Place of publication Baltimore, MD, U.S.A.
Publisher Lippincott Williams & Wilkins for the American Heart Association
Collection year 2011
Language eng
Formatted abstract
We thank Sealey et al for their interest in our article and their comments. They point out that plasma renin activity (PRA) in our study likely overestimated the true activity of circulating PRA and, by calculating the effective PRA, our results would be predictable. Suppressed PRA is a marker of volume overload and can occur with high dietary salt ingestion. Theoretically, patients with suppressed PRA might achieve greater blood pressure (BP) reductions with a low-salt diet than patients with high PRA because of greater salt sensitivity.

A treatment strategy on the basis of calculation of effective PRA to guide treatment is an exciting idea, but additional studies are needed to evaluate the efficacy of this approach.
© 2010 American Heart Association, Inc.
Keyword Resistant hypertension
Blood-pressure
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under "Letters to the Editor". In response to Sealey, J.E., Parra, D., Rosenstein, R., Laragh, J.H. "Effective" plasma renin activity: A derived measure for assessing residual plasma renin activity in patients taking angiotensin- converting enzyme inhibitors or angiotensin receptor blockers (2010) Hypertension, 55 (3), pp. e16.

Document type: Journal Article
Sub-type: Discussion - responses, round table/panel discussions, Q&A, reply
Collections: UQ Centre for Clinical Research Publications
Non HERDC
School of Medicine Publications
 
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Created: Sun, 07 Mar 2010, 00:04:27 EST