Group B Streptococcus (GBS) urinary tract infection involves binding of GBS to bladder uroepithelium and potent but GBS-specific induction of interleukin 1 alpha

Ulett, Glen C., Webb, Richard I., Ulett, Kimberly B., Cui, Xiangqin, Benjamin, William H., Crowley, Michael and Schembri, Mark A. (2010) Group B Streptococcus (GBS) urinary tract infection involves binding of GBS to bladder uroepithelium and potent but GBS-specific induction of interleukin 1 alpha. The Journal of Infectious Diseases, 201 6: 866-870. doi:10.1086/650696


Author Ulett, Glen C.
Webb, Richard I.
Ulett, Kimberly B.
Cui, Xiangqin
Benjamin, William H.
Crowley, Michael
Schembri, Mark A.
Title Group B Streptococcus (GBS) urinary tract infection involves binding of GBS to bladder uroepithelium and potent but GBS-specific induction of interleukin 1 alpha
Formatted title
Group B Streptococcus (GBS) urinary tract infection involves binding of GBS to bladder uroepithelium and potent but GBS-specific induction of interleukin 1α
Journal name The Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
1537-6613
Publication date 2010-03-15
Sub-type Article (original research)
DOI 10.1086/650696
Volume 201
Issue 6
Start page 866
End page 870
Total pages 5
Place of publication Cary, N C, United States
Publisher Oxford University Press
Collection year 2011
Language eng
Subject 0605 Microbiology
1103 Clinical Sciences
1108 Medical Microbiology
1117 Public Health and Health Services
Formatted abstract
Group B Streptococcus (GBS) causes urinary tract infections, but the pathogenic mechanisms underlying GBS urinary tract infections are unknown. We investigated whether uropathogenic GBS can bind to bladder uroepithelium to initiate urinary tract infection. Uropathogenic GBS isolated from a patient with acute cystitis bound to human T24 bladder uroepithelial cells in close association with F‐actin in statistically significantly higher numbers compared with nonuropathogenic GBS. In vivo modeling using transurethrally infected mice revealed superior fitness of uropathogenic GBS for bladder colonization and potent uropathogenic GBS–specific up‐regulation of interleukin 1α during infection. Thus, binding of uropathogenic GBS to uroepithelium and vigorous induction of interleukin 1α represents the initial stages of GBS urinary tract infection.
© 2010 by the Infectious Diseases Society of America. All rights reserved.

Keyword Nonpregnant Adults
Agalactiae Infections
Females
IL-1-Beta
Males
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Brief report

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
Centre for Microscopy and Microanalysis Publications
 
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Created: Sun, 07 Mar 2010, 10:03:18 EST