A convenient new route to enantiopure 3-hydroxy-5-oxo esters and 5,6-dihydropyran-2-ones: intricacies of the trithioorthoester protecting group

Grange, Rebecca L. and Williams, Craig M. (2010) A convenient new route to enantiopure 3-hydroxy-5-oxo esters and 5,6-dihydropyran-2-ones: intricacies of the trithioorthoester protecting group. Tetrahedron Letters, 51 8: 1158-1160. doi:10.1016/j.tetlet.2009.12.058


Author Grange, Rebecca L.
Williams, Craig M.
Title A convenient new route to enantiopure 3-hydroxy-5-oxo esters and 5,6-dihydropyran-2-ones: intricacies of the trithioorthoester protecting group
Journal name Tetrahedron Letters   Check publisher's open access policy
ISSN 0040-4039
1873-3581
Publication date 2010-02
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.tetlet.2009.12.058
Volume 51
Issue 8
Start page 1158
End page 1160
Total pages 3
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Collection year 2011
Language eng
Abstract 3-Hydroxy-5-oxo esters are useful precursors to biologically active compounds. An expedient three-step synthesis of 3-hydroxy-5-oxo esters based on dithiane anion chemistry is presented along with the transformation of the 3-hydroxy-5-oxo esters into 5,6-dihydropyran-2-ones.
Keyword Multicomponent Linchpin Couplings
Coa reductase inhibitors
Anion relay chemistry
3 hydroxy 5 oxo ester derivative
5,6 dihydropyran 2 one derivative
Trithioorthoester
Ester derivative
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online December 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Sun, 07 Mar 2010, 00:00:44 EST