LV Volumes but not filling pressure are determinants of survival in critically ill patients

Sturgess, David J., Venkatesh, Bala, Joyce, Christopher J., Jones, Mark and Marwick, Thomas H. (2006). LV Volumes but not filling pressure are determinants of survival in critically ill patients. In: Circulation. Abstracts From Scientific Sessions 2006. Scientific Sessions 2006, Chicago, IL, USA, (II_369-II_369). 12-15 November 2006.

Author Sturgess, David J.
Venkatesh, Bala
Joyce, Christopher J.
Jones, Mark
Marwick, Thomas H.
Title of paper LV Volumes but not filling pressure are determinants of survival in critically ill patients
Conference name Scientific Sessions 2006
Conference location Chicago, IL, USA
Conference dates 12-15 November 2006
Proceedings title Circulation. Abstracts From Scientific Sessions 2006   Check publisher's open access policy
Place of Publication Baltimore, MD., USA
Publisher Lippincott, Williams & Wilkins for the American Heart Association
Publication Year 2006
Sub-type Poster
ISSN 0009-7322
Volume 114
Issue 18, Supplement
Start page II_369
End page II_369
Total pages 1
Language eng
Abstract/Summary Background: Transthoracic echocardiography (TTE) is able to assess LV volumes as well as LV filling pressure (from the ratio of mitral E velocity/mitral annular tissue velocity [E/e’]). E/e’ predicts outcome after infarction but its prognostic value in critical illness is undefined. The aim of this study was to evaluate the prognostic significance of echocardiographic LV volumes and filling pressure in the critically ill. Methods: A consecutive group of 94 patients (66M, 28F, 61±15 years) who had standard TTE supplemented by measurement of E/e’ in a combined medical and surgical tertiary referral ICU were enrolled. TTE was performed 5±6 days after ICU admission. Severity of critical illness was assessed using APACHE III. Survival analysis was based on 28-day survival from date of echo with patients discharged alive censored at the time of leaving hospital. Results are presented as mean±SD. Results: Mean APACHE III score was 72±25, and length of stay in ICU was 11±11 days and in hospital 32±48 days. Hospital mortality was 33% (n=31); correlates of hospital mortality are summarized in Table 1. Univariate analysis of survival obtained similar results. The independent predictors of survival were APACHE III risk of hospital death (HR 1.3 (95%CI 1.1–1.5), p=0.003), and increased LVESV (HR 2.1 (95%CI 1.2–3.7), p=0.007). Peak E velocity and E/e’ were not predictors of survival. Table 1. Univariate analysis of hospital mortality Conclusion: In this cohort of critically ill patients, LVESV but not E/e’ is a highly significant predictor of survival that adds incremental value to APACHE III derived prediction.
Subjects 1102 Cardiovascular Medicine and Haematology
1103 Clinical Sciences
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Abstract number: 1864

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Created: Fri, 05 Mar 2010, 12:36:11 EST by Laura McTaggart on behalf of Faculty Of Health Sciences