Indian Hedgehog is essential for definitive Haematopoiesis in the fetal liver

Cridland, Simon and Perkins, Andrew C. (2007). Indian Hedgehog is essential for definitive Haematopoiesis in the fetal liver. In: Blood. 49th Annual Meeting of the American Society of Hematology, Atlanta, Georgia, USA, (652A-652A). December 8-11.


Author Cridland, Simon
Perkins, Andrew C.
Title of paper Indian Hedgehog is essential for definitive Haematopoiesis in the fetal liver
Conference name 49th Annual Meeting of the American Society of Hematology
Conference location Atlanta, Georgia, USA
Conference dates December 8-11
Proceedings title Blood   Check publisher's open access policy
Journal name Blood   Check publisher's open access policy
Place of Publication Washington, D.C., USA
Publisher American Society of Hematology
Publication Year 2007
Sub-type Poster
ISSN 0006-4971
1528-0020
Volume 110
Issue 11
Start page 652A
End page 652A
Total pages 1
Language eng
Abstract/Summary Indian hedgehog (Ihh) is a member of the hedgehog family of secreted proteins which play diverse roles in development. Members of this family have established roles in craniofacial development, long bone formation and spermatogenesis. Mammals have three hedgehog proteins which all act through the Patched receptor to activate smoothened and downstream zinc finger transcription factors of the Gli family. Ihh can induce differentiation of primitive red blood cells during primitive streak formation, and definitive red blood cells from CD34+ cord blood stem cells. Both Ihh and the Patched receptor are expressed in the fetal liver. In this report we show Ihh knockout mice display a partially penetrant defect in fetal liver haematopoiesis characterised by severe anaemia and apoptosis of the fetal liver erythroid compartment. Primitive haematopoiesis is normal, so mutant embryos survive until ~E14. Components of the hedgehog signalling pathway are expressed in stromal, stem cell and progenitor cell components of the haematopoietic system. Lastly, fetal liver progenitor cells (CFU-e, BFU-e, and myeloid CFUs) are normal in Ihh null mice, suggesting a critical requirement for Ihh in the fetal liver stem cell niche.
Subjects 1103 Clinical Sciences
1102 Cardiovascular Medicine and Haematology
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Abstract number: 2192

 
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Created: Fri, 05 Mar 2010, 20:51:32 EST by Laura McTaggart on behalf of Institute for Molecular Bioscience