Delayed P2X4R expression after hypoxia-ischemia is associated with microglia in the immature rat brain.

Wixey, Julie A, Reinebrant, Hanna E, Carty, Michelle L. and Buller, Kathryn M. (2009) Delayed P2X4R expression after hypoxia-ischemia is associated with microglia in the immature rat brain.. Journal of Neuroimmunology, 212 1-2: 35-43. doi:10.1016/j.jneuroim.2009.04.016


Author Wixey, Julie A
Reinebrant, Hanna E
Carty, Michelle L.
Buller, Kathryn M.
Title Delayed P2X4R expression after hypoxia-ischemia is associated with microglia in the immature rat brain.
Journal name Journal of Neuroimmunology   Check publisher's open access policy
ISSN 0165-5728
Publication date 2009-07
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.jneuroim.2009.04.016
Volume 212
Issue 1-2
Start page 35
End page 43
Total pages 9
Editor Cedric S Raine
Place of publication Amstedam, The Netherlands
Publisher Elsevier BV
Collection year 2010
Language eng
Subject C1
920501 Child Health
111401 Foetal Development and Medicine
Abstract In a preterm hypoxia-ischemia model in the post-natal day 3 rat, we characterized how the expression of purine ionotropic P2X(4) receptors change in the brain post-insult. After hypoxia-ischemia, P2X(4) receptor expression increased significantly and was associated with a late increase in ionised calcium binding adapter molecule-1 protein expression indicative of microglia cell activation. Minocycline, a potent inhibitor of microglia, attenuated the hypoxia-ischemia-induced increase in P2X(4) receptor expression. We postulate that P2X(4) receptor-positive microglia may represent a population of secondary injury-induced activated microglia. Future studies will determine whether this population contributes to the progression of injury in the immature brain
Keyword Hypoxia ischemia
Microglia
P2X4 receptor
Minocycline
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
2010 Higher Education Research Data Collection
 
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Created: Thu, 04 Mar 2010, 15:51:04 EST by Ian Sawyer on behalf of UQ Centre for Clinical Research