A novel synthetic adjuvant enhances dendritic cell function

Phillipps, Karen S. M., Wykes, Michelle N., Liu, Xue Q., Brown, Melissa, Blanchfield, Joanne T. and Toth, Istvan (2009) A novel synthetic adjuvant enhances dendritic cell function. Immunology, 128 1: e582-e588. doi:10.1111/j.1365-2567.2008.03038.x


Author Phillipps, Karen S. M.
Wykes, Michelle N.
Liu, Xue Q.
Brown, Melissa
Blanchfield, Joanne T.
Toth, Istvan
Title A novel synthetic adjuvant enhances dendritic cell function
Journal name Immunology   Check publisher's open access policy
ISSN 0019-2805
Publication date 2009-09-01
Year available 2008
Sub-type Article (original research)
DOI 10.1111/j.1365-2567.2008.03038.x
Volume 128
Issue 1
Start page e582
End page e588
Total pages 7
Place of publication United Kingdom
Publisher Wiley-Blackwell Publishing Ltd.
Language eng
Abstract The lipid core peptide (LCP) is a novel, synthetic, self-adjuvanted vaccine delivery system that neatly incorporates the adjuvant, carrier and antigenic peptides of a vaccine into a single molecular entity. This system has been previously shown to efficiently deliver vaccines and induce immunity. Because adjuvants target sentinels of the immune response, such as dendritic cells (DCs), that are widely distributed throughout the body to initiate specific immune responses, we investigated the effects of the adjuvant on DCs. Here we show that LCP targets vaccines to DCs and induces their activation.
Keyword Adjuvant
Dendritic cells
LCP system
Toll-like receptor 2
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 05 Mar 2010, 00:48:47 EST by Jennifer Falknau on behalf of School of Chemistry & Molecular Biosciences