Trafficking, development and hedgehog

Simpson, Fiona, Kerr, Markus C. and Wicking, Carol (2009) Trafficking, development and hedgehog. Mechanisms of Development, 126 5 - 6: 279-288. doi:10.1016/j.mod.2009.01.007


Author Simpson, Fiona
Kerr, Markus C.
Wicking, Carol
Title Trafficking, development and hedgehog
Journal name Mechanisms of Development   Check publisher's open access policy
ISSN 0925-4773
Publication date 2009-05-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.mod.2009.01.007
Volume 126
Issue 5 - 6
Start page 279
End page 288
Total pages 10
Editor M. Leptin
Place of publication Ireland
Publisher Elsevier
Language eng
Subject 970106 Expanding Knowledge in the Biological Sciences
060403 Developmental Genetics (incl. Sex Determination)
CX
Abstract Embryogenesis is mediated by a relatively small number of developmental signaling pathways, and the morphogens, receptors and transcription factors integral to these cascades are considered the master regulators of development. However, superimposed on this is an additional layer of control by complex intracellular trafficking networks. The importance of trafficking in controlling the processes of morphogenesis and development is highlighted by recent data regarding the transport and localisation of the morphogen sonic hedgehog (Shh) and the machinery that leads to its secretion, modification, cellular internalisation and signal transduction. Here we review the regulation of hedgehog signaling by intracellular trafficking, including the role of the primary cilium and lipids in mediating pathway activity.
Keyword Hedgehog signaling
Trafficking
Rab23
Cilia
Intraflagellar transport
Patched
Smoothened
Gli
Sterols
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 39 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 41 times in Scopus Article | Citations
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Created: Thu, 04 Mar 2010, 19:02:29 EST by Susan Allen on behalf of Institute for Molecular Bioscience