The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors

Town, Liam, McGlinn, Edwina, Fiorenza, Salvatore, Metzis, Vicki, Butterfield, Natalie C., Richman, Joy M. and Wicking, Carol (2009) The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors. Developmental Dynamics, 238 12: 3175-3184. doi:10.1002/dvdy.22126


Author Town, Liam
McGlinn, Edwina
Fiorenza, Salvatore
Metzis, Vicki
Butterfield, Natalie C.
Richman, Joy M.
Wicking, Carol
Title The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors
Formatted title
The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors
Journal name Developmental Dynamics   Check publisher's open access policy
ISSN 1058-8388
1097-0177
Publication date 2009-12
Sub-type Article (original research)
DOI 10.1002/dvdy.22126
Volume 238
Issue 12
Start page 3175
End page 3184
Total pages 10
Editor Gary C. Schoenwolf
Place of publication Hoboken, NJ, U. S. A.
Publisher John Wiley & Sons
Collection year 2010
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
060403 Developmental Genetics (incl. Sex Determination)
Formatted abstract
Pitrm1 is a zinc metalloendopeptidase that has been implicated in Alzheimer's disease and mitochondrial peptide degradation, but to date no major role in embryonic development has been documented. In a screen for genes regulated by hedgehog signaling in the mouse limb, we showed that expression of Pitrm1 is upregulated in response to loss of the Gli3 transcription factor. Here we confirm spatial changes in Pitrm1 expression in the Gli3 mutant mouse limb and examine Pitrm1 expression in Shh null and Ptch1 conditional deletion mouse mutants. In wild-type mice, Pitrm1 is expressed in a number of developing tissues known to be patterned by Sonic hedgehog, including the limbs, face, cortex, hippocampus, cerebellum, tectum, sub-mandibular gland, lung, genital tubercle, hair follicles, and the enamel knot of the teeth. Additionally, Pitrm1 is expressed in Pax3-expressing myoblast progenitors in the limb, the dermomyotome, and developing muscles of the face and torso.
Keyword Pitrilysin
Pitrm1
hMP1
PreP
Ntup1
Hedgehog
Shh
Gli3
Ptch
Pax3
Myo-progenitor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
ERA 2012 Admin Only
Institute for Molecular Bioscience - Publications
 
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Created: Thu, 04 Mar 2010, 08:42:34 EST by Susan Allen on behalf of Institute for Molecular Bioscience