Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods.

Tapsall, John, Read, Phillip, Carmody, Christopher, Bourne, Christopher, Ray, Sanghamitra, Limnios, Athena, Sloots, Theo and Whiley, David (2009) Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods.. Journal of Medical Microbiology, 58 5: 683-687. doi:10.1099/jmm.0.007641-0


Author Tapsall, John
Read, Phillip
Carmody, Christopher
Bourne, Christopher
Ray, Sanghamitra
Limnios, Athena
Sloots, Theo
Whiley, David
Title Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods.
Journal name Journal of Medical Microbiology   Check publisher's open access policy
ISSN 0022-2615
Publication date 2009-05
Year available 2009
Sub-type Article (original research)
DOI 10.1099/jmm.0.007641-0
Volume 58
Issue 5
Start page 683
End page 687
Total pages 5
Editor Charles Penn
Place of publication United Kingdom
Publisher Society for General Microbiology
Collection year 2010
Language eng
Subject 060502 Infectious Agents
060501 Bacteriology
060503 Microbial Genetics
C1
920203 Diagnostic Methods
Abstract Diagnostic, genotypic and antibiotic-resistance determinants of Neisseria gonorrhoeae were analysed by molecular methods to verify the failure of ceftriaxone treatment in two cases of pharyngeal gonorrhoea. Monoplex assays were needed to define competitive inhibition of a positive Chlamydia PCR in a duplex assay. Different penA changes were detected in the N. gonorrhoeae isolated from the two cases. These were associated with raised ceftriaxone MICs of 0.03 and 0.016 mg 1-1• which may have contributed to the treatment failures in these cases.
Formatted abstract
Diagnostic, genotypic and antibiotic-resistance determinants of Neisseria gonorrhoeae were analysed by molecular methods to verify the failure of ceftriaxone treatment in two cases of pharyngeal gonorrhoea. Monoplex assays were needed to define competitive inhibition of a positive Chlamydia PCR in a duplex assay. Different penA changes were detected in the N. gonorrhoeae isolated from the two cases. These were associated with raised ceftriaxone MICs of 0.03 and 0.016 mg 1-1, which may have contributed to the treatment failures in these cases.
Keyword ceftrizxone
Treatment
gonorrhoea
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Wed, 03 Mar 2010, 14:41:39 EST by Lesley Arnicar on behalf of Clinical Medical Virology Centre