Concurrent Alzheimer's disease-related pathology lowers the threshold for developing dementia in argyrophilic grain disease

Thal, Dietmar R., Schultz, Christian, Botez, Giovannina, Robert, Mrak E., Griffin, Sue T., Wiestler, Otmar D., Braak, Heiko and Ghebremedhin, Estifanos (2004). Concurrent Alzheimer's disease-related pathology lowers the threshold for developing dementia in argyrophilic grain disease. In: Neurobiology of Aging. Abstracts from the 9th International Conference on Alzheimer's Disease and Related Disorders. 9th International Conference on Alzheimer's Disease and Related Disorders, Philadelphia, Pennsylvania, U.S.A., (S408-S409). 17-22 July 2004. doi:10.1016/S0197-4580(04)81338-1


Author Thal, Dietmar R.
Schultz, Christian
Botez, Giovannina
Robert, Mrak E.
Griffin, Sue T.
Wiestler, Otmar D.
Braak, Heiko
Ghebremedhin, Estifanos
Title of paper Concurrent Alzheimer's disease-related pathology lowers the threshold for developing dementia in argyrophilic grain disease
Conference name 9th International Conference on Alzheimer's Disease and Related Disorders
Conference location Philadelphia, Pennsylvania, U.S.A.
Conference dates 17-22 July 2004
Proceedings title Neurobiology of Aging. Abstracts from the 9th International Conference on Alzheimer's Disease and Related Disorders   Check publisher's open access policy
Journal name Neurobiology of Aging   Check publisher's open access policy
Place of Publication Oxford, U.K
Publisher Elsevier Inc.
Publication Year 2004
Sub-type Poster
DOI 10.1016/S0197-4580(04)81338-1
ISSN 0197-4580
Volume 25
Issue Supplement 2
Start page S408
End page S409
Total pages 2
Language eng
Abstract/Summary Background: Argyrophilic grain disease (AGD) constitutes a neurodegenerative disorder that occurs in the brains of the elderly and affects 5% of all patients with dementia, tan-protein-containing lesions known as argyrophilic grains in neuronal processes and coiled bodies in oligodendrocytes characterize this disease. Dementia is encountered in only a subset of cases that display the morphological pattern of AGD at autopsy. Objective: To determine the role of concurrent Alzheimer's disease (AD)-related pathology for the development of dementia in AGD patients. Methods: Autopsy brains from 30 demented and 49 non-demented AGD patients, from 46 AD patients and from 86 non-demented controls without AGD were staged for the distribution of AD-related neurofibrillary changes and amyloid 13-protein (AI3) deposits. To identify differences in the distribution of AD-related pathology between demented and non-demented AGD cases, and to differentiate the pattern of AD-related changes in AGD cases from that seen in AD and non-demented controls, we compared the distribution of AI3-deposits and neurofibrillary changes among these groups of cases. Differences in the stages of the distribution of neurofibrillary changes and A[3-deposits among these groups were analyzed statistically. Conclusions: Demented AGD patients exhibited significantly higher stages of AD-related AI3-deposition and neurnfibrillary tangle pathology as compared to non-demented AGD cases, but significantly lower stages of both lesions compared to AD without AGD. In conclusion, AGD is a clinically relevant neurodegenerative entity that significantly lowers the threshold for developing dementia when it is associated with AD-related pathology.
Subjects 1103 Clinical Sciences
1109 Neurosciences
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Poster number: P3-186

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Google Scholar Search Google Scholar
Created: Wed, 03 Mar 2010, 12:06:41 EST by Laura McTaggart on behalf of Faculty of Science