A comparison of AD brain pathology for men and women throughout adulthood

Corder, Elizabeth H., Ghebremedhin, Estifanos, Taylor, Miles G., Thal, Dietmar R., Ohm, Thomas G. and Braak, Heiko (2004). A comparison of AD brain pathology for men and women throughout adulthood. In: Neurobiology of Aging. Abstracts from the 9th International Conference on Alzheimer's Disease and Related Disorders. 9th International Conference on Alzheimer's Disease and Related Disorders, Philadelphia, Pennsylvania, USA, (S308-S308). 17-22 July 2004. doi:10.1016/S0197-4580(04)81012-1


Author Corder, Elizabeth H.
Ghebremedhin, Estifanos
Taylor, Miles G.
Thal, Dietmar R.
Ohm, Thomas G.
Braak, Heiko
Title of paper A comparison of AD brain pathology for men and women throughout adulthood
Conference name 9th International Conference on Alzheimer's Disease and Related Disorders
Conference location Philadelphia, Pennsylvania, USA
Conference dates 17-22 July 2004
Proceedings title Neurobiology of Aging. Abstracts from the 9th International Conference on Alzheimer's Disease and Related Disorders   Check publisher's open access policy
Journal name Neurobiology of Aging   Check publisher's open access policy
Place of Publication Oxford, UK
Publisher Elsevier Inc.
Publication Year 2004
Sub-type Poster
DOI 10.1016/S0197-4580(04)81012-1
ISSN 0197-4580
1558-1497
Volume 25
Issue Supplement 2
Start page S308
End page S308
Total pages 1
Language eng
Abstract/Summary Background: Epidemiologic studies indicate that women are at higher risk for the development of AD compared to men. Clinical studies have not been verified by neuropathologic findings. Objective(s): We compared the extent of AD changes for men and women at age 25 and each decade of age thereafter to age 95. Methods: information on Braak staging for SP (none, A to C) and NFT (none, I to VI) was available for more than 5000 subjects ascertained at routine autopsy. About a third of the subjects had APOE genotype information. Linear models were constructed. Results: There was on average over all APOE genotypes (n > 5000) a 3-year acceleration of NFT staging for women. In more detail, men and women had the same likelihood for NFT at the initial predilection site in the transentorhinal cortex (I). But, women were more likely to reach stages II (entorhinal) and III (hippocampal) clearly evident at ages 65 (p = 0.01) and 75 (p = 0.01). Isocortical stages IV to VI were also more common for women. Looking at subjects who had APOE information, there was no gender gap for APOE2/3+ subjects. There was a large gender gap for APOE4+ subjects. In addition, women at early NFT stages I to IiI APOE4+ and in late middle age were much more likely to have extensive SP deposits throughout the brain compared to APOFA+ men. Conclusions: APOE4+ women had more brain regions containing NFT and SP compared to APOFA+ men of the same age from about age 55 years onward. The rapid increase in AD neuropathology in late middle age for a subgroup of women argues in favor of development of early interventional strategies to be selectively applied and for better genetic definition of the high-risk subgroup.
Subjects 1109 Neurosciences
1103 Clinical Sciences
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Abstract number: P2-267

 
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