Positioning of mitochondria to Ca2+ release units in muscle is developmentally regulated and stabilized by tethers

Boncompagni, S., Rossi, A. E., Micaroni, M., Beznoussenko, G. V., Polishchuk, R. S., Dirksen, R. T. and Protasi, F. (2008). Positioning of mitochondria to Ca2+ release units in muscle is developmentally regulated and stabilized by tethers. In: Journal of Muscle Research and Cell Motility. XXXVIIth European Muscle Conference of the European Society for Muscle Research, Oxford, UK, (285-285). 13–16 September 2008. doi:10.1007/s10974-008-9161-x


Author Boncompagni, S.
Rossi, A. E.
Micaroni, M.
Beznoussenko, G. V.
Polishchuk, R. S.
Dirksen, R. T.
Protasi, F.
Title of paper Positioning of mitochondria to Ca2+ release units in muscle is developmentally regulated and stabilized by tethers
Formatted title
Positioning of mitochondria to Ca2+ release units in muscle is developmentally regulated and stabilized by tethers
Conference name XXXVIIth European Muscle Conference of the European Society for Muscle Research
Conference location Oxford, UK
Conference dates 13–16 September 2008
Proceedings title Journal of Muscle Research and Cell Motility   Check publisher's open access policy
Place of Publication Netherlands
Publisher Springer
Publication Year 2008
Sub-type Oral presentation
DOI 10.1007/s10974-008-9161-x
ISSN 0142-4319
1573-2657
Volume 29
Issue 6-8
Start page 285
End page 285
Total pages 1
Language eng
Formatted Abstract/Summary
Bi-directional Ca2+ signaling between mitochondria and intracellular
stores (endoplasmic/sarcoplasmic reticulum) underlies important
cellular functions including oxidative ATP production. In striated
muscle, this coupling is achieved by mitochondria being located
adjacent to the junctional sarcoplasmic reticulum (jSR). We used
confocal and electron microscopy/tomography to characterize the
mechanisms responsible for orchestrating and maintaining mitochondrial/
jSR association during postnatal development. We find that
association of mitochondria with the jSR is a highly coordinated
process that involves a progressive shift from longitudinal mitochondrial
clustering at birth to highly specific positioning next to
SR Ca2+ release units (CRUs) in adult muscle. Mitochondrial-CRU
‘‘coupling’’ is achieved by the small bridges, or tethers, that link the
outer mitochondrial membrane to the jSR. In summary, we characterized
a developmentally regulated ‘‘anchoring system’’ stabilized
by tethers that provides a structural framework for bi-directional
SR-mitochondrial signalling in striated muscle.
Subjects 0601 Biochemistry and Cell Biology
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Session 7: Muscle Development and Redevelopment Abstract number: 7.07

 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 02 Mar 2010, 14:48:45 EST by Laura McTaggart on behalf of Institute for Molecular Bioscience