Correlations between the hoehn and yahr stages and cognitive status of idiopathic Parkinson's disease patients, and the neuropathological stages of Parkinson's disease

Rueb, U., Del Tredici, K., De Vos, R. A. I., Jansen Steur, E., Ghebremedhin, E., Deller, T. and Braak, H. (2004). Correlations between the hoehn and yahr stages and cognitive status of idiopathic Parkinson's disease patients, and the neuropathological stages of Parkinson's disease. In: Amos D. Korczyn, Donald Calne and Eric C. Walters, Journal of the Neurological Sciences. Proceedings of: Dementia in Parkinson's Disease: International Symposium, Dementia in Parkinson's Disease: International Symposium. Dementia in Parkinson's Disease: International Symposium, Dementia in Parkinson's Disease: International Symposium, Salzburg, Austria, (277-277). 24-27 October 2004. doi:10.1016/j.jns.2006.05.047


Author Rueb, U.
Del Tredici, K.
De Vos, R. A. I.
Jansen Steur, E.
Ghebremedhin, E.
Deller, T.
Braak, H.
Title of paper Correlations between the hoehn and yahr stages and cognitive status of idiopathic Parkinson's disease patients, and the neuropathological stages of Parkinson's disease
Conference name Dementia in Parkinson's Disease: International Symposium, Dementia in Parkinson's Disease: International Symposium
Conference location Salzburg, Austria
Conference dates 24-27 October 2004
Proceedings title Journal of the Neurological Sciences. Proceedings of: Dementia in Parkinson's Disease: International Symposium, Dementia in Parkinson's Disease: International Symposium   Check publisher's open access policy
Place of Publication Amsterdam, Netherlands
Publisher Elsevier B.V.
Publication Year 2004
Sub-type Published abstract
DOI 10.1016/j.jns.2006.05.047
ISSN 0022-510X
Editor Amos D. Korczyn
Donald Calne
Eric C. Walters
Volume 248
Issue 1-2
Start page 277
End page 277
Total pages 1
Language eng
Abstract/Summary Although the Hoehn and Yahr staging system has proved a valuable tool for rating the progressive impairment of mobility in patients with idiopathic Parkinson's disease (PD), the information it provides is restricted solely to the motor aspects of PD. In order to obtain newer insights into the clinical course and its correlation with the underlying pathological process, we evaluated the association of the Hoehn and Yahrs (H&Y) stages, on the one hand, with the cognitive status of patients and the stages of the proposed neuropathological staging procedure of PD. To this end: (1) the H&Y stages and the Mini Mental State Examination (MMSE) scores from the last neurological examination in 88 clinically PD patients prior to decease were assessed, (2) neuropathological staging was performed post-mortem on paraffinembedded tissue sections using immunoreactions against alpha-synuclein, and (3) statistical analysis was carried out by means of the Kruskal– Wallis H-Test and a nonparametric trend test. The H&Y stages showed a significant linear correlation with both the MMSE scores (Kruskal– Wallis H-Test: Hcorr=20.67; p<0.0005; nonparametric trend test: Hlin=12.06; p<0.01) and the neuropathological PD stages (Kruskal– Wallis H-Test: Hcorr=33.62; p<0.0005; nonparametric trend test: Hlin=16.39; p<0.0005). The results of our study indicate that: (1) The progressive impairment of mobility in PD patients is accompanied by an increasing risk of developing cognitive decline, and (2) the proposed neuropathological staging of PD reflects the progressive clinical course of the disease.
Subjects 110903 Central Nervous System
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Abstract number: 25

 
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