Parietal epithelial cells regenerate podocytes

Poulsom, Richard and Little, Melissa H. (2009) Parietal epithelial cells regenerate podocytes. Journal of the American Society of Nephrology, 20 2: 231-233. doi:10.1681/ASN.2008121279


Author Poulsom, Richard
Little, Melissa H.
Title Parietal epithelial cells regenerate podocytes
Journal name Journal of the American Society of Nephrology   Check publisher's open access policy
ISSN 1046-6673
1533-3450
Publication date 2009-02
Sub-type Editorial
DOI 10.1681/ASN.2008121279
Volume 20
Issue 2
Start page 231
End page 233
Total pages 3
Editor Bonnie O'Brien
Place of publication Washington , DC, United States
Publisher American Society of Nephrology
Collection year 2010
Language eng
Subject 970111 Expanding Knowledge in the Medical and Health Sciences
060103 Cell Development, Proliferation and Death
Abstract In response to acute damage, such as poisons, some fish display an effective neo-nephrogenic potential in adulthood whereby new nephrons form from a residual progenitor pool.1 In contrast, the response of kidney parenchyma in mammals seems restricted to proliferation of surviving tubule cells without new nephron production. Nephron formation is restricted to organogenesis in mammals because the progenitor population is exhausted before birth in humans and shortly afterward in mice.2 This scenario severely restricts the renal restoration of functional capacity after damage in mammals. So how does the adult kidney replenish cells lost through damage, aging, or, as occurs for podocytes, ongoing regular loss of viable cells into the urine?
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Editorial
Collections: 2010 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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Created: Mon, 01 Mar 2010, 12:37:32 EST by Susan Allen on behalf of Institute for Molecular Bioscience