Review article: Potential cellular therapies for renal disease: Can we translate results from animal studies to the human condition?

Little, Melissa and Rae, Fiona (2009) Review article: Potential cellular therapies for renal disease: Can we translate results from animal studies to the human condition?. Nephrology, 14 6: 544-553. doi:10.1111/j.1440-1797.2009.01144.x


Author Little, Melissa
Rae, Fiona
Title Review article: Potential cellular therapies for renal disease: Can we translate results from animal studies to the human condition?
Journal name Nephrology   Check publisher's open access policy
ISSN 1320-5358
1440-1797
Publication date 2009-09
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1440-1797.2009.01144.x
Volume 14
Issue 6
Start page 544
End page 553
Total pages 10
Place of publication Richmond, Vic., Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2010
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
060103 Cell Development, Proliferation and Death
Abstract The incidence of chronic kidney disease is increasing worldwide, prompting considerable research into potential regenerative therapies. These have included studies to determine whether an endogenous renal stem cell exists in the postnatal kidney and whether non-renal adult stem cells, such as mesenchymal stem cell, can ameliorate renal damage. Such stem cells will either need to be recruited to the damaged kidney to repair the damage in situ or be differentiated into the desired cell type and delivered into the damaged kidney to subsequently elicit repair without maldifferentiation. To date, these studies have largely been performed using experimental and genetic models of renal damage in rodents. The translation of such research into a therapy applicable to human disease faces many challenges. In this review, we examine which animal models have been used to evaluate potential cellular therapies and how valid these are to human chronic kidney disease.
Keyword Cell Differentiation
Chronic Kidney Disease (ckd)
Embryonic stem cell
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 01 Mar 2010, 11:48:55 EST by Susan Allen on behalf of Institute for Molecular Bioscience