Is there such a thing as a renal stem cell?

Little, M. H. and Bertram, J. F. (2009) Is there such a thing as a renal stem cell?. Journal of the American Society of Nephrology, 20 10: 2112-2117. doi:10.1681/ASN.2009010066

Author Little, M. H.
Bertram, J. F.
Title Is there such a thing as a renal stem cell?
Journal name Journal of the American Society of Nephrology   Check publisher's open access policy
ISSN 1046-6673
Publication date 2009-10
Year available 2009
Sub-type Article (original research)
DOI 10.1681/ASN.2009010066
Volume 20
Issue 10
Start page 2112
End page 2117
Total pages 6
Editor Bonnie O'Brien
Place of publication Washington DC U.S.A.
Publisher American Society of Nephrology
Collection year 2010
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
060103 Cell Development, Proliferation and Death
Abstract Increasing interest in the potential of adult stem cells in regenerative medicine has led to numerous studies focused on the identification of endogenous renal stem cells within the mature mammalian kidney. A variety of approaches have been taken to identify such cells, including physical location, cell surface marker expression, and functional properties. Proof of clonogenicity or renal potential remains questionable, and few such populations have been characterized in humans; however, recent evidence that even podocytes, a cell type with limited proliferative capacity under normal conditions, are constantly regenerated from a population within the Bowman's capsule has breathed new life into the quest for a renal stem cell. Here we examine whether current evidence is sufficient to conclude such a population does indeed exist or whether the jury is still out. We also ask which properties we would wish such a cell to possess to allow for repair of the diseased kidney.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 49 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 01 Mar 2010, 11:42:07 EST by Susan Allen on behalf of Institute for Molecular Bioscience