SoxF genes: Key players in the development of the cardio-vascular system

Francois, M, Koopman, P and Beltrame, M (2009) SoxF genes: Key players in the development of the cardio-vascular system. The International Journal of Biochemistry and Cell Biology, 42 3: 445-448. doi:10.1016/j.biocel.2009.08.017


Author Francois, M
Koopman, P
Beltrame, M
Title SoxF genes: Key players in the development of the cardio-vascular system
Journal name The International Journal of Biochemistry and Cell Biology   Check publisher's open access policy
ISSN 1357-2725
Publication date 2009-09-03
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.biocel.2009.08.017
Volume 42
Issue 3
Start page 445
End page 448
Total pages 4
Editor Geoffrey J Laurent
Place of publication Oxford, England, U. K.
Publisher Pergamon (Elsevier)
Collection year 2010
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
060403 Developmental Genetics (incl. Sex Determination)
Abstract SoxF genes (Sox7, Sox17 and Sox18) encode a group of transcription factors that have a pivotal role in cardio-vascular development. SOXF factors orchestrate endothelial cell fate or direct cell differentiation in developing heart, blood vessels and lymphatic vessels. Their roles are highly conserved throughout animal evolution. SOXF activity is finely tuned with a variety of cell type-specific co-factors and partner proteins to effect transcription of genes critical for endothelial cell phenotype and function. Because SOXF factors play a central role in cardiogenesis, vasculogenesis and lymphangiogenesis, SOXF gene mutations figure prominently in the aetiology of human vascular disease.
Keyword Sox
Transcription
Development
Cardio-vascular system
Genetics
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
 
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Created: Mon, 01 Mar 2010, 09:31:01 EST by Susan Allen on behalf of Institute for Molecular Bioscience