Quality of life and alternate nightly nocturnal home hemodialysis

van Eps, Carolyn L., Jeffries, Janine K., Johnson, David W., Campbell, Scott B., Isbel, Nicole M., Mudge, David W. and Hawley, Carmel M. (2010) Quality of life and alternate nightly nocturnal home hemodialysis. Hemodialysis International, 14 1: 29-38. doi:10.1111/j.1542-4758.2009.00419.x

Author van Eps, Carolyn L.
Jeffries, Janine K.
Johnson, David W.
Campbell, Scott B.
Isbel, Nicole M.
Mudge, David W.
Hawley, Carmel M.
Title Quality of life and alternate nightly nocturnal home hemodialysis
Journal name Hemodialysis International   Check publisher's open access policy
ISSN 1542-4758
Publication date 2010-01
Sub-type Article (original research)
DOI 10.1111/j.1542-4758.2009.00419.x
Volume 14
Issue 1
Start page 29
End page 38
Total pages 10
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Collection year 2011
Language eng
Subject C1
920204 Evaluation of Health Outcomes
110312 Nephrology and Urology
Abstract Hemodialysis has been associated with reduced quality of life (QOL). Small cohort studies of quotidian hemodialysis regimens suggest general QOL and dialysis-related symptoms may improve compared with conventional regimens. An observational cohort study was conducted on 63 patients (age 51.7 ± 12.9 years; 79.4% male; 33.3% diabetes; duration of renal replacement therapy 1.9 [0.7–6.4] years) converted from conventional home hemodialysis (3–5 sessions weekly, 3–6 h/session) to home nocturnal home hemodialysis (NHD) (3–5 sessions weekly, 6–10 h/session). Kidney Disease Quality of Life (KDQOL) and Assessment of Quality of Life instruments and 6-minute–walk tests were applied at baseline and 6 months. Baseline and 6 month surveys were returned by 70% of patients. On KDQOL, significant improvements in general health (P=0.02) and overall health ratings (P=0.0008), physical function (P=0.003), physical role (P=0.018), and energy and fatigue (P=0.027) were documented. There was a trend toward improvement in burden of kidney disease (P=0.05) and emotional role (P=0.066). There was a significant improvement in distance covered in the 6-minute–walk test from 513 m (420.5–576.4) to 536.5 m (459–609), P=0.007. On Assessment of Quality of Life, there was a trend toward improvement in overall utility score from 0.65 (0.39–0.81) to 0.73 (0.46–0.86), P=0.096. After 86.2 patient-years of observation, 23 patients have discontinued NHD (12 transplanted, 5 deceased, 4 psychosocial problems, 1 dialysis access problem, 1 medically unsuitable). Nocturnal home hemodialysis is a sustainable therapy. In addition to improving general QOL, alternate nightly NHD can significantly improve physical functioning as measured by KDQOL and 6-minute–walk tests. Copyright © 1999–2011 John Wiley & Sons, Inc. All Rights Reserved.
Keyword Nocturnal
Quality of life
6-minute-walk test
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 28 Feb 2010, 00:04:38 EST