Sensory regulation of neuroligins and neurexin I in the honeybee brain

Biswas, Sunita, Reinhard, Judith, Oakeshott, John, Russell, Robyn, Srinivasan, Mandyam V. and Claudianos, Charles (2010) Sensory regulation of neuroligins and neurexin I in the honeybee brain. PloS One, 5 2: e9133-1-e9133-10. doi:10.1371/journal.pone.0009133


Author Biswas, Sunita
Reinhard, Judith
Oakeshott, John
Russell, Robyn
Srinivasan, Mandyam V.
Claudianos, Charles
Title Sensory regulation of neuroligins and neurexin I in the honeybee brain
Formatted title
Sensory regulation of neuroligins and neurexin I in the honeybee brain
Journal name PloS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2010-02-09
Sub-type Article (original research)
DOI 10.1371/journal.pone.0009133
Open Access Status DOI
Volume 5
Issue 2
Start page e9133-1
End page e9133-10
Total pages 10
Place of publication San Francisco, CA, United Sates
Publisher Public Library of Science
Collection year 2011
Language eng
Subject 06 Biological Sciences
1109 Neurosciences
Formatted abstract
Background: Neurexins and neuroligins, which have recently been associated with neurological disorders such as autism in humans, are highly conserved adhesive proteins found on synaptic membranes of neurons. These binding partners produce a trans-synaptic bridge that facilitates maturation and specification of synapses. It is believed that there exists an optimal spatio-temporal code of neurexin and neuroligin interactions that guide synapse formation in the postnatal developing brain. Therefore, we investigated whether neuroligins and neurexin are differentially regulated by sensory input using a behavioural model system with an advanced capacity for sensory processing, learning and memory, the honeybee.

Methodology/Principal Findings:
Whole brain expression levels of neuroligin 1–5 (NLG1–5) and neurexin I (NrxI) were estimated by qRT-PCR analysis in three different behavioural paradigms: sensory deprivation, associative scent learning, and lateralised sensory input. Sensory deprived bees had a lower level of NLG1 expression, but a generally increased level of NLG2–5 and NrxI expression compared to hive bees. Bees that had undergone associative scent training had significantly increased levels of NrxI, NLG1 and NLG3 expression compared to untrained control bees. Bees that had lateralised sensory input after antennal amputation showed a specific increase in NLG1 expression compared to control bees, which only happened over time.

Conclusions/Significance:
Our results suggest that (1) there is a lack of synaptic pruning during sensory deprivation; (2) NLG1 expression increases with sensory stimulation; (3) concomitant changes in gene expression suggests NrxI interacts with all neuroligins; (4) there is evidence for synaptic compensation after lateralised injury.
© 2010 Biswas et al
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number: e9133, pp.1-10

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Queensland Brain Institute Publications
ERA 2012 Admin Only
 
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Created: Sun, 28 Feb 2010, 00:01:32 EST