D–serine localisation in the human and rat retina

Pow, D. V., Williams, S. M. and Sullivan, R. K. P. (2004). D–serine localisation in the human and rat retina. In: Investigative Ophthalmology & Visual Science.. Association of Research for Vision in Ophthalmology (ARVO) 2004 Annual Meeting, Ft. Lauderdale, Florida, U. S. A., (U103-U103). 25-29 April 2004.


Author Pow, D. V.
Williams, S. M.
Sullivan, R. K. P.
Title of paper D–serine localisation in the human and rat retina
Conference name Association of Research for Vision in Ophthalmology (ARVO) 2004 Annual Meeting
Conference location Ft. Lauderdale, Florida, U. S. A.
Conference dates 25-29 April 2004
Proceedings title Investigative Ophthalmology & Visual Science.   Check publisher's open access policy
Place of Publication Rockville, MD, U. S. A.
Publisher Association for Research in Vision and Ophthalmology
Publication Year 2004
ISSN 0146-0404
1552-5783
Volume 45
Issue Supp. 2
Start page U103
End page U103
Total pages 1
Language eng
Formatted Abstract/Summary
Purpose
D–serine is a potent co–agonist at the NMDA receptor. We have created a new antibody that can detect D–serine in paraformaldehyde–fixed tissues, in order to determine its distribution relative to other neurochemical markers including amino acid neurotransmitters and their transporters.

Conclusions
Our data suggest that D–serine system may be dynamically modulated under physiological conditions. As the availability of D–serine may influence efficacy of NMDA–mediated neurotransmission we speculate that it may be a significant factor in excitotoxicity in conditions such as glaucoma.
© 2004, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved.
Subjects 1113 Ophthalmology and Optometry
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Published as "E-Abstract 3285—B920".

 
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Created: Fri, 26 Feb 2010, 13:19:46 EST by Jon Swabey on behalf of Faculty Of Health Sciences