Brain responses to hypoxia in the intrauterine growth restricted piglet measured by magnetic resonance spectroscopy and diffusion weighted imaging

Sinclair, K., Rose, S., Cowin, G., Burke, C. and Colditz, P. (2005). Brain responses to hypoxia in the intrauterine growth restricted piglet measured by magnetic resonance spectroscopy and diffusion weighted imaging. In: Robert P. Lisak, Journal of the Neurological Sciences. Abstracts of the XVIIIth World Congress of Neurology. XVIIIth World Congress of Neurology, Sydney, Australia, (S262-S262). 5-11 November 2005.


Author Sinclair, K.
Rose, S.
Cowin, G.
Burke, C.
Colditz, P.
Title of paper Brain responses to hypoxia in the intrauterine growth restricted piglet measured by magnetic resonance spectroscopy and diffusion weighted imaging
Conference name XVIIIth World Congress of Neurology
Conference location Sydney, Australia
Conference dates 5-11 November 2005
Proceedings title Journal of the Neurological Sciences. Abstracts of the XVIIIth World Congress of Neurology   Check publisher's open access policy
Journal name Journal of the Neurological Sciences   Check publisher's open access policy
Place of Publication Amsterdam, The Netherlands
Publisher Elsevier BV
Publication Year 2005
Sub-type Poster
ISSN 0022-510X
Editor Robert P. Lisak
Volume 238
Issue Supp. 1
Start page S262
End page S262
Total pages 1
Language eng
Formatted Abstract/Summary
Background: Intrauterine growth restriction (IUGR) is associated with chronic fetal hypoxia and an increased incidence of neurodevelopmental disability. The pathophysiology linking IUGR and brain injury is not well understood.
Hypothesis: Newborn IUGR piglets, compared to appropriately grown (AGA) littermates, have a different acute cellular and metabolic response to hypoxia.
Methods: Eight pairs of piglet littermates < 24 h age were selected by weight, (IUGR < 5th percentile, AGA > 25th percentile). Piglets were anaesthetised, ventilated, physiological parameters monitored and normothermia maintained. Proton magnetic resonance spectroscopy (1H-MRS) was performed in a aT magnet to measure brain lactate, and diffusion weighted imaging (DWI) performed to calculate the apparent diffusion coefficient (ADC), wlffch reflects cellular edema associated with hypoxic primary energy failure. Measurements were made at eight-minute intervals before, during and for two hours after an hypoxic stimulus (FiO2 4% for 25 min).
Results: Peak lactate (mean ± SD) was 0.09 ± 0.04 for controls and 0.27 ± 0.16 for IUGR (p - 0.007, unpaired t-test). ADC values were 85.5 ± 1.9 for controls and 74.4 ± 11 for IUGR (p - 0.02). IUGR piglets had a relatively uniform exaggerated lactate peak. Lactate and ADC values altered values concurrently however the decrease in ADC
was more varied, suggesting that some IUGR piglets were particularly vulnerable to the acute hypoxic stress and manifest more edema.
Conclusion: Compared to normal weight piglets, IUGR piglets have a different acute cellular and metabolic response to all acute hypoxic stimulus which may place them at increased risk of neurodevelopmental disability.

Subjects 1109 Neurosciences
1103 Clinical Sciences
Keyword Intrauterine growth restriction (IUGR)
Neurodevelopmental disability
Chronic fetal hypoxia
Brain injury
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Poster Abstract #0641

 
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Created: Thu, 25 Feb 2010, 14:31:21 EST by June Temby on behalf of Faculty of Science