Mouse germ cell development: From specification to sex determination

Ewen, Katherine A. and Koopman, Peter (2010) Mouse germ cell development: From specification to sex determination. Molecular and Cellular Endocrinology, 323 1: 76-93. doi:10.1016/j.mce.2009.12.013


Author Ewen, Katherine A.
Koopman, Peter
Title Mouse germ cell development: From specification to sex determination
Journal name Molecular and Cellular Endocrinology   Check publisher's open access policy
ISSN 0303-7207
Publication date 2010-07-08
Year available 2009
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.mce.2009.12.013
Volume 323
Issue 1
Start page 76
End page 93
Total pages 18
Place of publication Clare, Ireland
Publisher Elsevier Ireland
Collection year 2010
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
060403 Developmental Genetics (incl. Sex Determination)
Abstract Primordial germ cells (PGCs) are embryonic progenitors for the gametes. In the gastrulating mouse embryo, a small group of cells begin expressing a unique set of genes and so commit to the germline. Over the next 3–5 days, these PGCs migrate anteriorly and increase rapidly in number via mitotic division before colonizing the newly formed gonads. PGCs then express a different set of unique genes, their inherited epigenetic imprint is erased and an individual methylation imprint is established, and for female PGCs, the silent X chromosome is reactivated. At this point, germ cells (GCs) commit to either a female or male sexual lineage, denoted by meiosis entry and mitotic arrest, respectively. This developmental program is determined by cues emanating from the somatic environment. Crown copyright © 2009 Published by Elsevier Ireland Ltd.
Keyword Germ Cell
Gonad
Specification
Migration
Proliferation
Epigenetics
Differentiation In-vitro
Meiosis
Mitotic arrest
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 28 December 2009

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: 2010 Higher Education Research Data Collection
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 53 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 62 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 25 Feb 2010, 12:14:49 EST by Susan Allen on behalf of Institute for Molecular Bioscience