Ovarian steroids modulate neuroendocrine dysfunction in polycystic ovary syndrome

Doi, S. A. R., Al-Zaid, M., Towers, P. A., Scott, C. J. and Al-Shoumer, K. A. S. (2005) Ovarian steroids modulate neuroendocrine dysfunction in polycystic ovary syndrome. Journal of Endocrinological Investigation, 28 10: 882-892.

Author Doi, S. A. R.
Al-Zaid, M.
Towers, P. A.
Scott, C. J.
Al-Shoumer, K. A. S.
Title Ovarian steroids modulate neuroendocrine dysfunction in polycystic ovary syndrome
Journal name Journal of Endocrinological Investigation   Check publisher's open access policy
ISSN 0391-4097
Publication date 2005-11
Sub-type Article (original research)
Volume 28
Issue 10
Start page 882
End page 892
Total pages 11
Place of publication Italy
Publisher Editrice Kurtis s.r.l.
Language eng
Subject 11 Medical and Health Sciences
1103 Clinical Sciences
Formatted abstract
Objective
Neuroendocrine dysfunction in polycystic ovary syndrome (PCOS) was addressed by studying the steroid hormone changes in women with PCOS with either high or normal LH levels leading to inferences regarding the primacy of elevated LH in the pathophysiology of PCOS.
Methods
A cross-sectional study was designed in an academic clinical facility involving 234 women with PCOS. Patients were divided into two groups based on an LH/FSH ratio < or >1 and hormonal and metabolic studies were performed in both groups. Factors were determined by binomial logistic regression that predicted group membership of these women.
Results
Higher follicular phase estradiol (E2) and androstenedione (A4) levels as well as greater insulin sensitivity were the only factors that predicted the presence of neuroendocrine dysfunction with elevated A4 being necessary for neuroendocrine dysfunction.
Conclusions
It was concluded that uncoupling of hypothalamic E2 inhibition by elevated ovarian A4 associated with E2 related sensitization of pituitary LH leads to neuroendocrine dysfunction in PCOS.
Keyword Polycystic ovary
Steroid LH
Pituitary
Hypothalamus
Gonadotropin releasing hormone
Luteinizing hormone
Insulin resistance
Idiopathic hirsutism
Glucose tolerance
Hyperandrogenic women
Pulse generator
Normal menses
Sex steroids
Thecal cells
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 24 Feb 2010, 14:05:00 EST