Irregular cycles and steroid hormones in polycystic ovary syndrome

Doi, S. A. R., Al-Zaid, M., Towers, P. A., Scott, C. J. and Al-Shoumer, K. A. S. (2005) Irregular cycles and steroid hormones in polycystic ovary syndrome. Human Reproduction, 20 9: 2402-2408. doi:10.1093/humrep/dei093

Author Doi, S. A. R.
Al-Zaid, M.
Towers, P. A.
Scott, C. J.
Al-Shoumer, K. A. S.
Title Irregular cycles and steroid hormones in polycystic ovary syndrome
Journal name Human Reproduction   Check publisher's open access policy
ISSN 0268-1161
Publication date 2005-09
Sub-type Article (original research)
DOI 10.1093/humrep/dei093
Volume 20
Issue 9
Start page 2402
End page 2408
Total pages 7
Publisher Oxford University Press on behalf of the European Society of Human Reproduction and Embryology
Language eng
Subject 11 Medical and Health Sciences
1103 Clinical Sciences
Formatted abstract
This cross-sectional study was undertaken to evaluate the factors that relate to menstrual status (oligo-amenorrhoea versus eumenorrhoea) in polycystic ovary syndrome (PCOS).
A total of 234 women with clinical and biochemical features suggestive of PCOS underwent metabolic and hormonal evaluation. A forward stepwise logistic regression model was created based on the results to determine variables related to ovulatory status.
Only follicular phase progesterone and estradiol (E2) were retained in the final model. This model correctly classified 80% of PCOS women by ovulatory status. Univariate analysis revealed no difference in progesterone between ovulatory groups but E2 was higher in anovulatory groups. This suggested interaction between progesterone and E2 and the single interaction variable (progesterone/E2) also classified 80% of women by ovulatory status correctly.
The results suggest that a low ratio of progesterone to E2 is associated with menstrual irregularity and ovulatory status in PCOS.
Keyword Estradiol
Polycystic ovaries
Follicle-stimulating hormone
In-vitro Fertilization
Clomiphene citrate
Idiopathic hirsutism
Luteinizing hormone
Ovulation induction
Aromatase inhibitor
Insulin resistance
Pulse generator
Normal menses
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 24 Feb 2010, 14:03:37 EST