Disaccarides for drug discovery

Abbenante, Giovani, Adamson, George, Becker, Bernd, Drinnan, Nicholas, Barry, Grathwohl, Matthias, Meutermans, Wim, Rajaratnam, Premraj, Thanh Le, Giang, Tometzki, Gerald and West, Michael, Leo (2003). Disaccarides for drug discovery. WO/2003/093286; PCT/AU2003/000494.

Creator Abbenante, Giovani
Adamson, George
Becker, Bernd
Drinnan, Nicholas, Barry
Grathwohl, Matthias
Meutermans, Wim
Rajaratnam, Premraj
Thanh Le, Giang
Tometzki, Gerald
West, Michael, Leo
Patent title Disaccarides for drug discovery
Date of issue 2003-11-13
Patent owner Alchemia Limited
Patent number WO/2003/093286; PCT/AU2003/000494
Country of origin Australia
Language eng
Subjects 1101 Medical Biochemistry and Metabolomics
110102 Medical Biochemistry: Carbohydrates
Abstract/Summary Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function and other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalised about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.
Keyword Disaccharides
Combinatorial libraries

Document type: Patent
Collection: Institute for Molecular Bioscience - Publications
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Created: Wed, 24 Feb 2010, 09:45:10 EST by Macushla Boyle on behalf of Institute for Molecular Bioscience