Common genetic influences underlie comorbidity of migraine and endometriosis

Nyholt, Dale R., Gillespie, Nathan G., Merikangas, Kathleen R., Treloar, Susan A., Martin, Nicholas G. and Montgomery, Grant W. (2009) Common genetic influences underlie comorbidity of migraine and endometriosis. Genetic Epidemiology, 33 2: 105-113. doi:10.1002/gepi.20361

Author Nyholt, Dale R.
Gillespie, Nathan G.
Merikangas, Kathleen R.
Treloar, Susan A.
Martin, Nicholas G.
Montgomery, Grant W.
Title Common genetic influences underlie comorbidity of migraine and endometriosis
Journal name Genetic Epidemiology   Check publisher's open access policy
ISSN 0741-0395
Publication date 2009-02
Sub-type Article (original research)
DOI 10.1002/gepi.20361
Open Access Status
Volume 33
Issue 2
Start page 105
End page 113
Total pages 8
Place of publication New York, U.S.
Publisher Alan R. Liss
Language eng
Subject 11 Medical and Health Sciences
1117 Public Health and Health Services
111799 Public Health and Health Services not elsewhere classified
Abstract We examined the co-occurrence of migraine and endometriosis within the largest known collection of families containing multiple women with surgically confirmed endometriosis and in an independent sample of 815 monozygotic and 457 dizygotic female twin pairs. Within the endometriosis families, a significantly increased risk of migrainous headache was observed in women with endometriosis compared to women without endometriosis (odds ratio [OR] 1.57, 95% confidence interval [CI]: 1.12-2.21, P=0.009). Bivariate heritability analyses indicated no evidence for common environmental factors influencing either migraine or endometriosis but significant genetic components for both traits, with heritability estimates of 69 and 49%, respectively. Importantly, a significant additive genetic correlation (rG = 0.27, 95% CI: 0.06-0.47) and bivariate heritability (h2=0.17, 95% CI: 0.08-0.27) was observed between migraine and endometriosis. Controlling for the personality trait neuroticism made little impact on this association. These results confirm the previously reported comorbidity between migraine and endometriosis and indicate common genetic influences completely explain their co-occurrence within individuals. Given pharmacological treatments for endometriosis typically target hormonal pathways and a number of findings provide support for a relationship between hormonal variations and migraine, hormone-related genes and pathways are highly plausible candidates for both migraine and endometriosis. Therefore, taking into account the status of both migraine and endometriosis may provide a novel opportunity to identify the genes underlying them. Finally, we propose that the analysis of such genetically correlated comorbid traits can increase power to detect genetic risk loci through the use of more specific, homogenous and heritable phenotypes. Genet. Epidemiol. 2008. © 2008 Wiley-Liss, Inc.
Keyword Comorbid carcinoma
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
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