Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis

Zhao, Zhen Zhen, Nyholt, Dale R., Thomas, Shane, Treloar, Susan A. and Montgomery, Grant W. (2008) Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis. Molecular Human Reproduction, 14 9: 531-538. doi:10.1093/molehr/gan043


Author Zhao, Zhen Zhen
Nyholt, Dale R.
Thomas, Shane
Treloar, Susan A.
Montgomery, Grant W.
Title Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis
Journal name Molecular Human Reproduction   Check publisher's open access policy
ISSN 1360-9947
1460-2407
Publication date 2008-09
Sub-type Article (original research)
DOI 10.1093/molehr/gan043
Volume 14
Issue 9
Start page 531
End page 538
Total pages 8
Place of publication Oxford, UK
Publisher Oxford University Press
Language eng
Subject 111799 Public Health and Health Services not elsewhere classified
Formatted abstract
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific angiogenic protein suspected to be involved in the pathogenesis of endometriosis by establishing a new blood supply to the human exfoliated endometrium. Several transcription factor-binding sites are found in the VEGF 5'-untranslated region and variation within the region increases the transcriptional activity. Six previous studies which tested between one and three single nucleotide polymorphisms (SNPs) in samples comprising 105–215 cases and 100–219 controls have produced conflicting evidence for association between the SNPs in the VEGF region and endometriosis. To further investigate the reported association between VEGF variants and endometriosis, we tested the four VEGF polymorphisms (–2578 A/C, rs699947; –460 T/C, rs833061; +405 G/C, rs2010963 and +936 C/T, rs3025039) in a large Australian sample of 958 familial endometriosis cases and 959 controls. We also conducted a literature-based review of all relevant association studies of these VEGF SNPs in endometriosis and performed a meta-analysis. There was no evidence for association between endometriosis and the VEGF polymorphisms genotyped in our study. Combined association results from a meta-analysis did not provide any evidence for either genotypic or allelic association with endometriosis. Our detailed review and meta-analysis of the VEGF polymorphisms suggests that genotyping assay problems may underlie the previously reported associations between VEGF variants and endometriosis.
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Public Health Publications
 
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Created: Tue, 23 Feb 2010, 11:47:05 EST by Laura McTaggart on behalf of Faculty Of Health Sciences