The ratio of high molecular weight (HMW) to total adiponectin correlates with insulin resistance in fatty liver disease

Nguyen, Thien, Murphy, Therese L., Lipka, Geraldine, Fletcher, Linda M. and Macdonald, Graeme A. (2008). The ratio of high molecular weight (HMW) to total adiponectin correlates with insulin resistance in fatty liver disease. In: Hepatology. The Liver Meeting 2008: 59th Annual Meeting of the American Association for the Study of Liver Diseases. The Liver Meeting 2008: 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), San Francisco, CA, United States, (848A-848A). 31 October-4 November 2008. doi:10.1002/hep.22645


Author Nguyen, Thien
Murphy, Therese L.
Lipka, Geraldine
Fletcher, Linda M.
Macdonald, Graeme A.
Title of paper The ratio of high molecular weight (HMW) to total adiponectin correlates with insulin resistance in fatty liver disease
Conference name The Liver Meeting 2008: 59th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
Conference location San Francisco, CA, United States
Conference dates 31 October-4 November 2008
Proceedings title Hepatology. The Liver Meeting 2008: 59th Annual Meeting of the American Association for the Study of Liver Diseases   Check publisher's open access policy
Place of Publication Hoboken, NJ, United States
Publisher Wiley Interscience
Publication Year 2008
Year available 2008
Sub-type Poster
DOI 10.1002/hep.22645
Open Access Status
ISSN 0270-9139
1527-3350
Volume 48
Issue S1
Start page 848A
End page 848A
Total pages 1
Language eng
Formatted Abstract/Summary
Background and Aim
Adiponectin, an insulin-sensitizing adipokine, is present in serum as multimers of varying size. High molecular weight (HWM) multimers appear to play a major role in hepatic insulin sensitivity, which in turn has been
implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Therefore, our aim was to study the relationship between adiponectin multimers and NAFLD.

Methods
The study population consisted of 32 patients with NAFLD
(19 male), 21 with chronic HBV (10 male) and 28 healthy volunteers (15 male). The ratio of HMW: Total adiponectin (know as Sa) was determined by velocity sedimentation, followed by SDS-PAGE and Western blotting. Sa was correlated with BMI, age, ALT, AST, lipids, insulin resistance (as determined by the HOMA score).

Results
Serum triglycerides were higher and HDL cholesterol lower in NAFLD patients compared with controls (p < 0.0001). The Sa in NAFLD (0.35 ± 0.15) was significantly lower than in patients with HBV (0.52 ± 0.13, p<0.0001) or healthy volunteers (0.54 ± 0.16, p< 0.0001). As expected, the Sa was significantly higher in females than males (p = 0.0002) in the control group, however this was not seen in either liver disease groups. There was a negative correlation
between the Sa and HOMA in the NAFLD group (p=0.006).

Conclusions
The ratio of HMW to total adiponectin correlates
with the presence of NAFLD. This suggests adiponectin multimers may be involved in the pathogenesis of NAFLD
Subjects 110309 Infectious Diseases
110307 Gastroenterology and Hepatology
1103 Clinical Sciences
Keyword Liver disease
Hepatitis
Fatty liver
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Poster Session II - Sunday, November 2, 2008. Poster # 1212

 
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Created: Tue, 23 Feb 2010, 11:14:47 EST by Macushla Boyle on behalf of Faculty Of Health Sciences