Role of voltage-gated calcium channels in ascending pain pathways

Zamponi, G. W., Lewis, R. J., Todorovic, S. M., Arneric, S. P. and Snutch, T. P. (2009) Role of voltage-gated calcium channels in ascending pain pathways. Brain Research Revues, 60 1: 84-89. doi:10.1016/j.brainresrev.2008.12.021


Author Zamponi, G. W.
Lewis, R. J.
Todorovic, S. M.
Arneric, S. P.
Snutch, T. P.
Title Role of voltage-gated calcium channels in ascending pain pathways
Journal name Brain Research Revues   Check publisher's open access policy
ISSN 0165-0173
Publication date 2009-04
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.brainresrev.2008.12.021
Volume 60
Issue 1
Start page 84
End page 89
Total pages 6
Editor Floyd E Bloom
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2010
Language eng
Subject C1
8608 Human Pharmaceutical Products
860899 Human Pharmaceutical Products not elsewhere classified
110906 Sensory Systems
Abstract Voltage gated calcium channels (VGCCs) are well established mediators of pain signals in primary afferent neurons. N-type calcium channels are localized to synaptic nerve terminals in laminae 1 and 2 of the dorsal horn where their opening results in the release of neurotransmitters such as glutamate and substance P. The contribution of N-type channels to the processing of pain signals is regulated by alternate splicing of the N-type channel gene, with unique N-type channel splice variants being expressed in small nociceptive neurons. In contrast, T-type VGCCs of the Cav3.2 subtype are likely localized to nerve endings where they regulate cellular excitability. Consequently, inhibition of N-type and Cav3.2 T-type VGCCs has the propensity to mediate analgesia. T-type channel activity is regulated by redox modulation, and can be inhibited by a novel class of small organic blockers. N-type VGCC activity can be potently inhibited by highly selective peptide toxins that are delivered intrathecally, and the search for small organic blockers with clinical efficacy is ongoing. Here, we provide a brief overview of recent advances in this area, as presented at the Spring Pain Research conference (Grand Cayman, 2008).
Keyword dorsal root ganglion
T-type channel
N-type channel
Conotoxin
Burst firing
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Mon, 22 Feb 2010, 12:18:40 EST by Susan Allen on behalf of Institute for Molecular Bioscience