Controlled release of an antibiotic, gentamicin sulphate, from gravity spun polycaprolactone fibers

Chang, H.-I., Lau, Y.-C., Yan, C. and Coombes, A. G .A. (2008) Controlled release of an antibiotic, gentamicin sulphate, from gravity spun polycaprolactone fibers. Journal of Biomedical Materials Research Part A, 84A 1: 230-237. doi:10.1002/jbm.a.31476


Author Chang, H.-I.
Lau, Y.-C.
Yan, C.
Coombes, A. G .A.
Title Controlled release of an antibiotic, gentamicin sulphate, from gravity spun polycaprolactone fibers
Journal name Journal of Biomedical Materials Research Part A   Check publisher's open access policy
ISSN 1549-3296
1552-4965
Publication date 2008-01-01
Year available 2007
Sub-type Article (original research)
DOI 10.1002/jbm.a.31476
Volume 84A
Issue 1
Start page 230
End page 237
Total pages 8
Place of publication Hoboken, N.J., U.S.A.
Publisher John Wiley & Sons
Language eng
Subject 111504 Pharmaceutical Sciences
Abstract The antibiotic, gentamicin sulphate (GS), was incorporated in gravity-spun polycaprolactone (PCL) fibers by spinning from particulate suspensions of the drug in PCL solution to produce a controlled delivery system. The production rate of GS-loaded PCL fibers was confined to the range 1-1.5 m/min and the fiber diameter to 170-220 m. The kinetics of drug release could be adjusted by varying the GS loading of the fibers and the suspension preparation conditions. Gradual release of 80% of the initial GS content was measured in phosphate buffered saline at 37°C over 50 days from fibers spun from nonhomogenized suspensions, whereas loss of this amount of antibiotic occurred in less than 10 days from fibers spun from homogenized suspensions. Studies of growth inhibition of Stapyhlococcus epidermidis in culture indicated that GS released after 2 weeks from PCL fibers retained antibacterial activity. This behavior recommends further investigation of PCL fibers for local delivery of antibiotics to combat infection associated with periodontal disease, musculoskeletal injuries, and implantation of fiber-based tissue substitutes such as vascular prostheses. © 2007 Wiley Periodicals
Keyword polycaprolactone
fibers
antibiotic
gentamicin sulphate
Q-Index Code C1
Q-Index Status Provisional Code
Additional Notes Published Online: Jul 2 2007

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Pharmacy Publications
 
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Created: Mon, 22 Feb 2010, 20:24:03 EST by Gerald Martin on behalf of Faculty of Science